Revisiting the role of acids and hydrogen bond acceptors in enamine formation†
Gerald B.
Hammond 
*a
and
Bo
Xu
*b
*a
and
Bo
Xu
*b
Abstract
A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported. Acids can accelerate the reaction but do not change the reaction equilibria. In comparison, hydrogen bond acceptors facilitate the enamine formation via their strong hydrogen bonding interaction with the water generated in the reaction.
- This article is part of the themed collections: Editor’s Collection and Synthetic methodology in OBC
Please wait while we load your content...
