Issue 10, 2020
From the journal:

Chemical Communications

A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission†

Zhe Chen,ab   Jingxiong Lu,bc   Fan Xiao,b   Yishun Huang,b   Xuanjun Zhang ORCID logo *a  and  Leilei Tian ORCID logo *b  

* Corresponding authors

a Cancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau, China
E-mail: xuanjunzhang@um.edu.mo

b Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, China
E-mail: tianll@sustech.edu.cn

c Institute of Medi-X, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, China

Abstract

A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer–monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.

Graphical abstract: A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC08093G
Article type
Communication
Submitted
15 ኦክቶ 2019
Accepted
23 ዲሴም 2019
First published
28 ዲሴም 2019

Chem. Commun., 2020,56, 1501-1504

Permissions

Request permissions

A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission

Z. Chen, J. Lu, F. Xiao, Y. Huang, X. Zhang and L. Tian, Chem. Commun., 2020, 56, 1501 DOI: 10.1039/C9CC08093G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements