Issue 53, 2017

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Abstract

Investigation into the biological function of 5-benzylidene-4-oxazolidinones revealed dose-dependent inhibition of biofilm formation in Methicillin-resistant S. aureus (MRSA). This structurally unusual class of small molecules inhibit up to 89% of biofilm formation with IC50 values as low as 0.78 μM, and disperse pre-formed biofilms with IC50 values as low as 4.7 μM. Together, these results suggest that 4-oxazolidinones represent new chemotypes to enable the study of bacterial biofilms with small molecule chemical probes.

Graphical abstract: 5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

Supplementary files

Article information

Article type
Communication
Submitted
10 ሜይ 2017
Accepted
16 ሜይ 2017
First published
16 ሜይ 2017

Chem. Commun., 2017,53, 7353-7356

5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus

G. A. Edwards, N. V. Shymanska and J. G. Pierce, Chem. Commun., 2017, 53, 7353 DOI: 10.1039/C7CC03626D

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