Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

Abstract

A modular total synthesis of the natural product (+)-varitriol (1) and seven analogs was achieved by using combined coinage metal catalysis. Starting from enynol 13, reagent-controlled introduction of stereogenic centers and efficient center-to-axis-to-center chirality transfer via α-hydroxyallene 5 afforded (+)-varitriol with 6.4% yield over 10 steps.