Issue 11, 2007

Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

Abstract

We describe the selective measurement of extracellularglutamate concentration in rodent brain using ceramic-based platinum microelectrode arrays (MEAs) coated with electropolymerized, over-oxidized polypyrrole (OPP) as a permselective barrier to interference from dopamine and ascorbate. OPP-coated MEAs displayed similar sensitivity (97 ± 9 nA µM−1 cm−2) and response time (ca. 1 s) to glutamate as previously described Nafion-coated MEAs but, unlike Nafion-coated MEAs, were unresponsive to 5 µM dopamine. Such OPP-coated MEAs afforded selective detection of evoked glutamate release in the dopamine-rich striatum of the mouse brain.

Graphical abstract: Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

Article information

Article type
Paper
Submitted
09 ሜይ 2007
Accepted
23 ኦገስ 2007
First published
19 ሴፕቴ 2007

Analyst, 2007,132, 1107-1111

Selective detection of extracellularglutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole

E. Walker, J. Wang, N. Hamdi, H. G. Monbouquette and N. T. Maidment, Analyst, 2007, 132, 1107 DOI: 10.1039/B706880H

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