Incorporation of hydrophobic helix-bundle peptides into lipid bilayer membranes facilitated by a peptide-umbrella structure

Abstract

Hydrophobic helical peptides, which are covered by hydrophilic peptides, are transferred into a phospholipid bilayer to form helix-bundle structures as a consequence of their peptide-umbrella structure.

References

1. B. L. Kieffer, Cell. Mol. Neurobiol., 1995, 15, 615.
2. N. Unwin, J. Mol. Biol., 1993, 229, 1101; U. Ludewig, M. Pusch and T. J. Jentsch, Nature, 1996, 383, 340.
3. A. Grove, M. Mutter, J. E. Rivier and M. Montal, J. Am. Chem. Soc., 1993, 115, 5919.
4. G. Von Heijne and C. Blomberg, Eur. J. Biochem., 1979, 97, 175.
5. S. Kimura, J. Zhao, Y. Imanishi, E. Okamura and J. Umemura, Peptide Chem., 1994, 133.
6. Y. Imanishi and S. Kimura, The Handbook of Nonmedical Applications of Liposomes Vol. II, Models for Biological Phenomena, ed. Y. Barenholz and D. D. Lasic, Boca Raton, 1996, pp. 189–200.
7. V. Janout, M. Lanier and S. L. Regen, J. Am. Chem. Soc., 1997, 119, 640.
8. K. Otoda, Y. Kitagawa, S. Kimura and Y. Imanishi, Biopolymers, 1993, 33, 1337.
9. K. Otoda, S. Kimura and Y. Imanishi, Biochim. Biophys. Acta, 1993, 1150, 1.
10. N. J. Gibson and J. Y. Cassim, Biochemistry, 1988, 28, 2134.
11. M. R. Eftink and C. A. Ghiron, Anal. Biochem., 1981, 114, 199.