In the current review, we have compiled the reports on the use of sulfoxonium ylides in metal-catalyzed C–H activation either as a coupling partner or as a directing group. These are further subdivided based on the metal-catalyst employed.
The distinctive specialities of gem-difluoromethylene alkynes, influenced by the adjacent gem-difluorine substituent, enhance their reactivity via multiple reaction mechanisms, facilitating a diverse array of transformations.
This review article summarizes the synthesis of iodonium ylides and its potential applications in C–H funtionalizations/annulations, including nitrogen heterocycles, oxygen heterocyles, alkenylations, etc.
A Rh(III)-catalyzed two-fold C–H activation of benzamidine hydrochlorides and cascade annulation with CF3-imidoyl sulfoxonium ylides (TFISYs) has been disclosed.
Amidine compounds, as important nitrogen analogues of isoelectronic carboxylic acids, are found throughout biologically active molecules and serve as the most attractive precursors for the synthesis of N-containing compounds.