This feature article comprehensively summarizes the recent advances in catalytic enantioselective construction of monofluoromethyl-substituted stereocenters.
A high yielding protocol for the synthesis of valuable monofluoromethyl ketones (MFMK) utilizing fluorobis(phenylsulfonyl)methane (FBSM) is presented.
Palladium-catalyzed regioselective carbomonofluoromethylation of unactivated alkenes for rapid access to γ-monofluoromethyl carboxylic acid derivatives is described.
An unprecedented nickel-catalysed enantioselective hydromonofluoromethylation of 1,3-enynes is developed, allowing access to valuable monofluoromethyl-tethered chiral allenes that are otherwise inaccessible.
An electrochemical monofluoroalkylation cyclization of N-arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed.