Amines, and in particular chiral amines are essential building blocks for the manufacture of active pharmaceutical ingredients. Continuous flow syntheses using immobilized transaminases pave the way to green and intensified production processes.
One-pot two-stage biocatalytic upgrading of biomass-derived aldehydes to optically active β-amino alcohols via sequential hydroxymethylation and asymmetric reduction amination.
Biocatalytic asymmetric ring-opening of meso-epoxides to chiral cyclic β-amino alcohols with good conversions and excellent enantioselectivity.
Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.
A new desing of microfluidic devices allows to screening variants of amine transaminase to find the optimal immobilization pairs to yield the microfluidic bioreactors with an optimal productivity/stability balance.