Suvankar Banerjee, Nilanjan Adhikari and Balaram Ghosh
RSC Med. Chem., 2026,17, 208-224
Abstract
Discovery timeline of HDAC8-degrading PROTACs.
Hinata Osawa, Kosuke Saito and Yosuke Demizu
RSC Med. Chem., 2025,16, 4721-4730
From themed collection:
Articles behind our 2025 journal covers
Abstract
Proteolysis-targeting chimeras (PROTACs) are emerging as powerful tools for targeted protein degradation.
Paul D. O’Dowd, Graeme P. Sullivan, Daniel A. Rodrigues, Tríona Ní Chonghaile and Darren M. Griffith
Chem. Commun., 2023,59, 12641-12644
Abstract
We report the development of the first metallo-PROTAC, specifically a Pt-PROTAC that effectively degrades select Pt(II)-binding proteins. Metallo-PROTACs will have important applications in identifying metal binding proteins and as chemotherapeutics.
Md Kabir, Xufen Yu, H. Ümit Kaniskan and Jian Jin
Chem. Soc. Rev., 2023,52, 4313-4342
From themed collection:
Modalities of induced proximity pharmacology: Degraders and Beyond themed collection
Abstract
This review summarizes the past and present advances in developing degraders of epigenetic targets which play critical roles in many crucial biological pathways and therefore, targeted for the discovery of therapeutics.
Savina Abraham Pol, Sara Liljenberg, Jack Barr, Gina Simon, Luis Wong-Dilworth, Danielle L. Paterson, Vladimir P. Berishvili, Francesca Bottanelli, Farnusch Kaschani, Markus Kaiser, Mariell Pettersson and Doris Hellerschmied
RSC Chem. Biol., 2024,5, 1232-1247
Abstract
Extending the applications of the SNAP-tag: VHL- and CRBN-recruiting SNAP-PROTACs provide a ready-to-use targeted protein degradation system for SNAP-fusion proteins.