Yossra Gharbi and Rocío Mercado
Digital Discovery, 2024,3, 2158-2176
Abstract
Machine learning (ML) accelerates PROTAC design by optimizing linkers and protein–ligase interactions, enabling selective protein degradation for therapeutic applications, particularly targeting previously undruggable proteins.
Urvashi Patel, Joshua P. Smalley and James T. Hodgkinson
RSC Chem. Biol., 2023,4, 623-634
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
A review on current proteolysis targeting chimeras (PROTACs) as chemical probes for histone deacetylase (HDAC) enzymes.
Jie Zhong, Ruiqi Zhao, Yuji Wang, Yu-xiong Su and Xinmiao Lan
Nanoscale, 2024,16, 4378-4391
From themed collection:
Recent Review Articles
Abstract
Schematic illustration of the combinational strategy of nanotechnology and PROTACs (Nano-PROTACs): the typical shortcomings of traditional PROTACs and the nanotechnology-based strategies for PROTAC drugs optimization.
Jinhan Sheng, Tianyu Ma, Yu Wu and Ming Wang
Chem. Commun., 2026,62, 2414-2427
From themed collection:
2026 Pioneering Investigator Collection
Abstract
This feature article highlights the most recent advances in nanoparticle-enabled delivery of proteolysis-targeting chimeras (PROTACs) for spatiotemporally controlled protein degradation.
Suvankar Banerjee, Nilanjan Adhikari and Balaram Ghosh
RSC Med. Chem., 2026,17, 208-224
Abstract
Discovery timeline of HDAC8-degrading PROTACs.