An aminocatalytic asymmetric [2 + 2] cycloaddition for the formation of bicyclo[2.1.1]hexanes is presented. The bicyclo[2.1.1]hexane scaffold is a potential aryl bioisostere and its complexity can be increased by several synthetic elaborations.
The recent advancements in single-electron nucleophilic organocatalysis that facilitates single-electron transfer between substrates through the formation of a covalent intermediate were summarized based on the type of catalyst.
This review has summarized the development of organocatalytic asymmetric [3 + 3] cycloadditions and given insights into the remaining challenges to promote the future development of this field.
Structure-based design of a branched version of a high affinity amylase inhibitor based on the natural product montbretin A allows derivatization and manipulation of physical properties while retaining potent (nM) inhibition.
Chiral C3-spiro-cyclopentaneoxindoles are primarily formed through organocatalysis (CA, NHC, CPA, HB, and PTC) using four types of substrates.