A SmI2-mediated reductive cyclisation using trifluoroacetamide groups as radical precursors and alkynes as radical acceptors, which is the first example of using an acyclic amide group in a reductive cyclisation, afforded 2-trifluoromethylindolines.
SmI2-mediated radical cyclization of a xanthate ester derived from a 1,3-disubstituted tetrahydro-β-carboline having an α,β-unsaturated ester appendage led to an indole-fused azabicyclo[3.3.1]nonane framework.
Seven nonulosonic acids (NulOs) have been synthesized from easily available threonine- and gluconolactone-derived building blocks through an SmI2-mediated imine/aldehyde reductive coupling.
This review highlights how radical retrosynthesis, leveraging modern methods developed in recent years, enables strategic bond disconnection in the synthesis of complex terpenoid natural products.
This comprehensive review describes the methodologies reported between 2020 and early 2025 for the synthesis of (hetero)bicyclo[2.1.1]hexane derivatives, organised by mechanisms and the exit vectors achieved.