A SmI2-mediated reductive cyclisation using trifluoroacetamide groups as radical precursors and alkynes as radical acceptors, which is the first example of using an acyclic amide group in a reductive cyclisation, afforded 2-trifluoromethylindolines.
SmI2-mediated radical cyclization of a xanthate ester derived from a 1,3-disubstituted tetrahydro-β-carboline having an α,β-unsaturated ester appendage led to an indole-fused azabicyclo[3.3.1]nonane framework.
Seven nonulosonic acids (NulOs) have been synthesized from easily available threonine- and gluconolactone-derived building blocks through an SmI2-mediated imine/aldehyde reductive coupling.
This review highlights how radical retrosynthesis, leveraging modern methods developed in recent years, enables strategic bond disconnection in the synthesis of complex terpenoid natural products.
The stereoselective total synthesis of kavaratamide A, a linear lipodepsipeptide isolated from Moorena bouillonii, a marine cyanobacterium from Kavaratti, India, was successfully achieved using a simple and efficient method.