We describe a simple and practical protocol utilizing 8% NIS in MTBE for efficient 1,2-cis glycosidations.
An effective ZnI2-mediated 1,2-cis-L-rhamnosylation strategy was achieved by employing a 2,3-O-(o-xylylene) rhamnose donor, and applied to assemble the core repeating tetrasaccharide unit of the S. pneumoniae 23F capsule polysaccharide.
Iron-catalyzed iodonium-ion promoted activation of conventional thioglycosides enables selective 1,2-cis furanoside formation from various donors and nucleophiles, with the C2 group influencing selectivity.
The capsular polysaccharide (CPS) is a major virulence factor of the pathogenic Acinetobacter baumannii and a promising target for vaccine development.
An iterative and stereodivergent approach to synthesize 2-oxo-oligopyrrolidines was developed. The synthetic compounds exhibited antiproliferative activity according to the number of pyrrolidine rings and their stereochemical configuration.