This review provides a mechanistic overview of asymmetric Fe, Cu, Pd, Rh, Au and heme-based enzymes catalyzed carbene insertion reactions to construct C–X (X = O, N, S, etc.) and C–C bonds, focusing on the stereochemical models.
In this review, we have showcased the diverse aspects of transition-metal catalysis, biocatalysis, and photocatalytic C(sp3)–H bond functionalization to access lactones and lactams.
Exploring the catalytic performance in the carbenoid-model-reaction of six self-sufficient P450s belonging to different families, and revealing their differences using molecular simulation.
A molecular level understanding into the role of mutations in a cytochrome P450 catalyzed enantiodivergent carbene insertion reaction is provided through the use of computational tools.
This article reviews the integration of multidisciplinary approaches, including protein engineering, computational biology, and nanoarchitectonics, to advance pharmaceutical enzyme biocatalysis.