We describe the base-mediated [3 + 2] cycloaddition reaction of di/trifluoromethylated hydrazonoyl chlorides with fluoronitroalkenes for the synthesis of densely functionalized 3-di/trifluoroalkyl-5-fluoropyrazoles with potent biological activity.
The synthesis of pyrrole-fused heterocycles is demonstrated using the first biomass-derived glucose-mediated one-pot multicomponent nitro reductive cyclization method.
A comparison of enantioselective aza-Henry reactions with both non-fluorinated and α-fluoro nitroalkanes reveals an unusual reversal of diastereoselection favoring the rare syn-aza-Henry product as a result of fluorine-based diastereodivergence.
A new approach to N-fused-[5,5]-annulated heterocycles is described based on oxidative annulation between nitroalkenes and azolium ylides in the presence of Cu(CF3COO)2.
This review summarises methods to synthesise and apply fluorine- and polyfluoroalkyl/aryl-substituted 1,2,3-triazoles. Focus is devoted to recent examples and those where the properties of both the 1,2,3-triazole and fluorine groups are important.