We describe the base-mediated [3 + 2] cycloaddition reaction of di/trifluoromethylated hydrazonoyl chlorides with fluoronitroalkenes for the synthesis of densely functionalized 3-di/trifluoroalkyl-5-fluoropyrazoles with potent biological activity.
The synthesis of pyrrole-fused heterocycles is demonstrated using the first biomass-derived glucose-mediated one-pot multicomponent nitro reductive cyclization method.
This review summarises methods to synthesise and apply fluorine- and polyfluoroalkyl/aryl-substituted 1,2,3-triazoles. Focus is devoted to recent examples and those where the properties of both the 1,2,3-triazole and fluorine groups are important.
Synthesis of fluorinated quaternary carbon centers by a series of asymmetric alkylation, arylation, Mannich, Michael addition, aldol, and allylation reactions.
The newest reports on the synthesis of fluorine-containing valuable biomolecules via the Horner–Wadsworth–Emmons reaction are presented.