Hydrogel platforms for engineered live biotherapeutics: materials, microbial integration and clinical potential

Emma Liane Etter, Sarah Thormann, Srilekha Venkatraman, Sri Sruthi Potluru and Juliane Nguyen

RSC Pharm., 2026, 3, 305
DOI: 10.1039/D5PM00304K

Magnetically targeted delivery of probiotics for controlled residence and accumulation in the intestine

Hanye Xing, Xingyu Liu, Ju Wang, Tao Zhou, Xiangxiang Jin, Rui Qiu, Yang Lu, Changhong Liu and Yonghong Song

Nanoscale, 2025, 17, 8588
DOI: 10.1039/D4NR04753B

Live bacteria microneedles for biomedical applications

Junfeng Feng, Yu Wang, Letong Huang, Kun Guo and Guangyan Du

J. Mater. Chem. B, 2026, 14, 3643
DOI: 10.1039/D6TB00056H

Microbial therapeutics for cancer: emerging strategies and biomedical applications

Meng Chen, Yupei Hu, Xiaozhen Zhou, Lili Xia, Chenyao Wu, Yu Chen and Wei Feng

Chem. Commun., 2025, 61, 14531
DOI: 10.1039/D5CC03618F

Engineering live cell surfaces with polyphenol-functionalized nanoarchitectures

Yunxiang He, Qinling Liu, Yuanmeng He, Siqi Deng and Junling Guo

Chem. Sci., 2025, 16, 3774
DOI: 10.1039/D4SC07198K

Biohybrid Living Material with Antibacterial and Regenerating Properties Based on Probiotic Bacteria Stress Metabolism Modulation

Alina V. Lokteva, Kristina O. Baskakova, Erik R. Gandalipov, Nikita S. Serov, Mariia A. Mikhailova and Elena I. Koshel

Macromolecular Bioscience, 2025, 25
DOI: 10.1002/mabi.202500452

Bacteriogenic metallic and semiconducting nano-system as a potential sustainable solution for one health complexities

Vishal Chaudhary, Sonu Sonu, Pankaj Raizada and Ajeet Kaushik

Advances in Colloid and Interface Science, 2025, 346, 103648
DOI: 10.1016/j.cis.2025.103648

Responsive nanomedicine strategies achieve pancreatic cancer precise theranostics

Fangjian Li, Zixiang Tang, Yating Zheng, Tao Jiang, Lin Deng, Wenjie Dai, Yuxing Zhao, Nan Zheng, Siman Liu, Yuxuan Fan, Sihan Lu, Yanxi Chen, Gang Liu, Yang Zhang and Yongfu Xiong

Bioactive Materials, 2026, 55, 334
DOI: 10.1016/j.bioactmat.2025.08.012

Probiotic Delivery Systems for Inflammatory Bowel Disease: Recent Advances and Translational Challenges

Haofan Liu, Lina Yang, Sicheng Huang, Yaqian He, Yinghua Xie, Yongshuai Jing, Beibei Hu, Zhongqiu Li, Haichao Bi and Zhiwei Li

Probiotics & Antimicro. Prot., 2026
DOI: 10.1007/s12602-026-10952-9

Recent advances in intelligent oxygen delivery systems for tissue regeneration

Xuehui Rui, Yiyang Jia, Ruochen Qiao, Xiaoting Peng, Yuchen Wang, Tao Li, Chuan Zhao and Jinhui Wu

Advanced Drug Delivery Reviews, 2025, 226, 115684
DOI: 10.1016/j.addr.2025.115684

Surface engineering of individual living Shewanella cells for enhanced bioelectricity generation in microbial fuel cells

Le Tao, Bolei Chen, Maoyong Song and Guibin Jiang

Electrochimica Acta, 2026, 546, 147802
DOI: 10.1016/j.electacta.2025.147802

Innovative Bacterial Therapies and Genetic Engineering Approaches in Colorectal Cancer: A Review of Emerging Strategies and Clinical Implications

Chunxiao Song and Chunwu Zhao

J. Microbiol. Biotechnol., 2024, 34, 2397
DOI: 10.4014/jmb.2408.08026

Targeting breast cancer: the promise of phage-based nanomedicines

Sarah Gholami, Hossein Saffarfar, Mohammad Reza Mehraban, Nastaran Safavi Ardabili, Anis Elhami, Sara Ebrahimi, Payam Ali-Khiavi, Reza Kheradmand, Seyedeh Farinaz Fattahpour and Ahmad Mobed

Breast Cancer Res Treat, 2025, 211, 561
DOI: 10.1007/s10549-025-07696-5

Harnessing engineered bacteria for revolutionizing cancer immunotherapy

Kan Zhou, Lei-Ming Cao, Han-Yue Luo, Kang-Ning Wang, Zhiyong Song and Lin-Lin Bu

Adv Compos Hybrid Mater, 2026, 9
DOI: 10.1007/s42114-026-01664-3

Cyborg microbe biohybrids with metal–organic coating layers: Strategies, functionalisation and potential applications

Zichen Wu, Ke Xu, Regina Huang, Xinna Wang, Jade Lee-Lee Teng, Xiaolin Yu, Lijian Jin, Quanli Li, Ken Cham-Fai Leung, Hai Ming Wong and Xuan Li

Materials Today Bio, 2025, 31, 101642
DOI: 10.1016/j.mtbio.2025.101642

Dual-Pronged Strategy on Autoimmune Uveitis by Topical Application of Bioactive Carbon Dots from Natural Herbs

Baorui Chu, Can Li, Helei Wang, Hongkun Fang, Xianyang Liu, Chao Wu, Fan Cao, Shuhao Zeng, Yakun Wang, Xinyuan Chen, Zhiqi Zhang, Shangze Gao, Rui Zhang, Yanyan Jiang, Jianqiao Li and Shengping Hou

ACS Nano, 2026
DOI: 10.1021/acsnano.5c20902

Microbially synthesized nanomaterials: Advances and applications in biomedicine

Junjie Pan, Huihui Qian, Yuejuan Sun, Yuqing Miao, Jiawen Zhang and Yuhao Li

Precision Medicine and Engineering, 2025, 2, 100019
DOI: 10.1016/j.preme.2025.100019

Self-Supported Printing of Gelatin Composite-Based Engineered Living Materials

Ayman Alghamdi, Chuanshen Zhou, Ali T. Shams, John-Thomas T. Robinson, Renjing Wang, Taylor Rawlinson, Hitomi Yamaguchi and Yong Huang

Journal of Manufacturing Science and Engineering, 2025, 147
DOI: 10.1115/1.4068939

Engineering encapsulated living bacteria for advanced healthcare management

Ming Teng, Xiaomin Luo, Jiang Chang, Chen Yang, Xiaomeng Zhang, Liuying Li, Xudan Liu, Ruizhi Zhi, Xu Guo and Xinhua Liu

Biotechnology Advances, 2025, 83, 108640
DOI: 10.1016/j.biotechadv.2025.108640

Technology Roadmap of Micro/Nanorobots

Xiaohui Ju, Chuanrui Chen, Cagatay M. Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C. Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A. Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D. Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D. Zarzar, C. Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H. Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G. Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J. Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang and Martin Pumera

ACS Nano, 2025, 19, 24174
DOI: 10.1021/acsnano.5c03911

Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges

Krupansh Desai, Joëlle Mekontso, Ketaki Deshpande and Sara Trujillo

ACS Biomater. Sci. Eng., 2025, 11, 2584
DOI: 10.1021/acsbiomaterials.5c00247

The M.I.O.C. (Microbiota, Inflammation, Obesity, Cancer) Network

Giuseppe Merra, Giada La Placa, Marcello Covino, Marcello Candelli, Antonio Gasbarrini and Francesco Franceschi

WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE, 2025, 22, 368
DOI: 10.37394/23208.2025.22.35

Smart Textiles with Living Interfaces: Microbiome–Electronics Integration for Advanced Skin Health Management

Hanbai Wu, Yang Ming, Shuo Shi, Chuanwei Zhi, Daming Chen, Xin Hu, Rujun Yu, Shuang Qiu, Hang Mei Leung, Jinlian Hu, Jooyoun Kim, Joanne Yip and Bin Fei

Adv. Fiber Mater., 2026, 8, 34
DOI: 10.1007/s42765-025-00625-7

Therapeutic potential of biomaterials in rescuing sensorineural hearing loss

Shanying Han, Weiwei He, Hao Wei, Weilan Xiong, Wen Yang, Xiaolong Zhao, Xinghua Tang and Jiangang Fan

Neuroscience, 2025, 589, 173
DOI: 10.1016/j.neuroscience.2025.10.038

Autonomous chemo-metabolic construction of anisotropic cell-in-shell nanobiohybrids in enzyme-powered cell microrobots

Nayoung Kim, Sang Yeong Han, Hyeong Bin Rheem, Hojae Lee and Insung S. Choi

Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.adu5451

Green-synthesized metal nanoparticles: a promising approach for accelerated wound healing

Sivakumar Singaravelu, Fezile Motsoene, Heidi Abrahamse and Sathish Sundar Dhilip Kumar

Front. Bioeng. Biotechnol., 2025, 13
DOI: 10.3389/fbioe.2025.1637589

Bioengineering Living Biohybrid Therapeutics for Synergistic H2S Gaseous‐Photothermal Cancer Eradication

Xiaolian Deng, Yingyi Zhang, Chenyao Wu, Yuelan Liang, Jianwei Ding, Chengjie Yu, Xingding Zhang, Yiliang Lin, Jianghui Liang, Fangfang Duan, Wei Feng, Yu Chen and Xiang Gao

Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202501621

Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiota Dysbiosis in Colitis by Scavenging Oxidative Stress and Restoring Immune Homeostasis

Huan Yang, Xu Zhang, Jianshuang Wu, Yao Xiao, Liangliang Dai, Gaoyang Wang, Xiaohong Zhang, Chenghu Hu, Shuixiang He and Zhang Yuan

ACS Appl. Mater. Interfaces, 2025, 17, 22245
DOI: 10.1021/acsami.4c22004

Carbon Quantum Dot‐Encapsulated Metal–Organic Framework Hybrids as Multifunctional Fluorescent Sensors for Oral Disease Biomarker Detection

Yasamin Ghahramani, Negar Hajipour, Omid Tavakkol, Mahnaz Gholami, Masoomeh Yari Kalashgrani, Vijayakameswara Rao Neralla, Wei‐Hung Chiang and Seyyed Mojtaba Mousavi

The Chemical Record, 2025, 25
DOI: 10.1002/tcr.202500146

Construction of biomimetic nanomedicine delivery system based on biomedical materials for treating brain diseases: A review

Zhihao Chen, Mengru Wu, Xiu Wang and Wanjun Liang

International Journal of Biological Macromolecules, 2026, 350, 151033
DOI: 10.1016/j.ijbiomac.2026.151033

Advances in carbon-based nanomaterials for biosensing and bioanalytical applications: from CNTs to graphene, MXenes, MOFs, and MIPs

Bharathi Natarajan, Palanisamy Kannan and Govindhan Maduraiveeran

Microchemical Journal, 2026, 223, 117315
DOI: 10.1016/j.microc.2026.117315

Programmable microbial therapeutics: advances in engineered bacteria for targeted in vivo delivery and precision medicine

Lu Zhao, Jiaoyu Xin, Mingyang Hu, Chenyu Xue and Na Dong

Journal of Advanced Research, 2025
DOI: 10.1016/j.jare.2025.10.028

Green nanomaterials from renewable Biomass: Sustainable Synthesis, environmental Applications, and Life-Cycle implications

Dilpreet Singh, Akshay Kumar, Pooja A. Chawla and Viney Chawla

Environmental Nanotechnology, Monitoring & Management, 2026, 25, 101146
DOI: 10.1016/j.enmm.2026.101146

Biomaterials as kinetic translators of microbial metabolite signaling in cardiovascular disease

Alireza Maboudi, Amirhossein Ashabi and Mohammad Tavakolifar

Materials Today Communications, 2026, 51, 114815
DOI: 10.1016/j.mtcomm.2026.114815

Spherical-shaped ZnO nanoparticles and their diverse surface morphological applications in various biological applications against ROS

P. Madhan Kumar, R. Babujanarthanam, R. Tamil Selvi, R. Ganesamoorthy, S. Jesu Jaya Sudan, K. Kasthuri and R. Parameswari

Appl. Phys. A, 2025, 131
DOI: 10.1007/s00339-025-08504-z

Green synthesis of silver nanoparticles using bacterial supernatant: multifaceted antibacterial activity and metabolomics-based elucidation of the synthesis mechanism

Geum-Jae Jeong, Ju-Hong Kang, Dong-Joo Park, Kyung-Jin Cho, Ye-Hyeon Jo, Hyo-Jin Kim, Won-Kyo Jung, Fazlurrahman Khan and Young-Mog Kim

Materials Today Nano, 2026, 33, 100727
DOI: 10.1016/j.mtnano.2025.100727