Coacervation for biomedical applications: innovations involving nucleic acids

Kimiasadat Mirlohi and Whitney C. Blocher McTigue

Soft Matter, 2025, 21, 8
DOI: 10.1039/D4SM01253D

Functionalities of pH-responsive DNA nanostructures in tumor-targeted strategies

Liyue Wen and Min Wang

J. Mater. Chem. B, 2024, 12, 12174
DOI: 10.1039/D4TB01883D

DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Zhaorong Sun, Yingjie Ren, Wenjun Zhu, Yuliang Xiao and Han Wu

Analyst, 2024, 149, 599
DOI: 10.1039/D3AN01871G

LSINCT5: a pivotal oncogenic long non-coding RNA in cancers

Sharanya K Sritharan, Amar Harris Arifin, Shamala Salvamani, Rhun Yian Koh and Baskaran Gunasekaran

Funct Integr Genomics, 2025, 25
DOI: 10.1007/s10142-025-01610-4

Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy

Donya Esmaeilpour, Matineh Ghomi, Ehsan Nazarzadeh Zare and Mika Sillanpää

ACS Appl. Bio Mater., 2025, 8, 4549
DOI: 10.1021/acsabm.5c00489

Fabrication of lactoferrin-chitosan-etoposide nanoparticles with melatonin via carbodiimide coupling: In-vitro & in-vivo evaluation for colon cancer

Harshvardhan Raval, Sankha Bhattacharya, Darshan Bhirud, Preeti Chidambar Sangave, Girdhari Lal Gupta, Gaurav Paraskar, Megha Jha, Satyam Sharma, Sateesh Belemkar, Devendra Kumar and Rahul Maheshwari

Journal of Controlled Release, 2025, 377, 810
DOI: 10.1016/j.jconrel.2024.11.077

“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems”

Sudharshan Reddy Dachani, Ankur Vashi, Anand Badrivishal Mundada, Pooja Anand Mundada, Shashi Ravi Suman Rudrangi, Samatha Rudrangi and Ruchi Tiwari

Polymer-Plastics Technology and Materials, 2025, 64, 911
DOI: 10.1080/25740881.2024.2440531

Stereochemistry of Phosphorothioate Linkages Impacts the Structure and Binding Affinity of Aptamers and DNAzymes

Sasha B. Ebrahimi, Matthew J. Eibling, Steve S. Englehart, John M. Campbell, Aston Liu, Charlotte M. Fare, Sujatha Sonti and Himanshu Bhattacharjee

Mol. Pharmaceutics, 2025, 22, 3198
DOI: 10.1021/acs.molpharmaceut.5c00117

β-Cyclodextrin-based polyelectrolyte complexes for drug delivery

Rongrong Zhao, Bo Tang, Zhuoya Xu and Guihua Fang

Coordination Chemistry Reviews, 2025, 534, 216581
DOI: 10.1016/j.ccr.2025.216581

Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies

Sourav Pal and Subhajit Mandal

Explor Neuroprot Ther, 2025, 5
DOI: 10.37349/ent.2025.1004111

Toward successful retinal drug delivery after intravitreal injection: Current strategies to overcome the inner limiting membrane

Kaat De Clerck, Stefaan De Smedt, Katrien Remaut and Karen Peynshaert

Journal of Controlled Release, 2025, 384, 113849
DOI: 10.1016/j.jconrel.2025.113849

Pure or blend: Microbial cultures in the race to optimize butanol production

Okezie Emmanuel, Rozina and Thaddeus C. Ezeji

Renewable and Sustainable Energy Reviews, 2025, 224, 116131
DOI: 10.1016/j.rser.2025.116131

Exploiting an evolutionary constraint: Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection

Shun Wang, Dong Niu, Jiaqi Hu, Weiqi Liu, Fuhua Gu, Liyang Guo, Yuquan Guo, Yongze Huang, Hao Chen, Chunli Chen and Jichang Li

International Journal of Biological Macromolecules, 2025, 321, 146394
DOI: 10.1016/j.ijbiomac.2025.146394

Engineered Bionanomaterials for Precision Delivery of Nucleic Acid Drugs

Xiaochun Bian, Zhiwei Luo, Bing Peng, Jiahui Chen, Pik Kwan Lo, Liping Zhou and Yongqiang Wen

Small, 2025
DOI: 10.1002/smll.202502667

Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise

Qinghe Meng, Mo Yang, Fei Xing, Zhenxia Xie, Yimeng Hao, Ping Jiang and Baiquan Xiao

Critical Reviews in Oncology/Hematology, 2025, 215, 104858
DOI: 10.1016/j.critrevonc.2025.104858

Advancements in SELEX Technology for Aptamers and Emerging Applications in Therapeutics and Drug Delivery

Liangjie Feng, Yu Sun, Wenshen Jia, Yang Yu, Chang Liu, Jing Yang, Yunxia Luan, Jin Chen and Fengchao Wang

Biomolecules, 2025, 15, 818
DOI: 10.3390/biom15060818

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar and Richard Laga

Journal of Polymer Science, 2025, 63, 1419
DOI: 10.1002/pol.20240970

Spermine Significantly Increases the Transfection Efficiency of Cationic Polymeric Gene Vectors

Yue Lv, Jiaoqin Xue, Pengfei Cui and Lin Qiu

Pharmaceutics, 2025, 17, 131
DOI: 10.3390/pharmaceutics17010131

Synergistic integration of rolling circle amplification and nuclease-resistant reporter DNA tetrahedron affords improved biostability and accelerated reaction kinetics for direct detection of microRNA from human serum

Lihong Chen, Jingyao Huang, Ning Huang, Weizhu Yang, Zhuqi Sui, Jia Zhao, Haiyan Dong, Jianguo Xu and Zhen Chi

Microchemical Journal, 2025, 213, 113743
DOI: 10.1016/j.microc.2025.113743

Integration of Hybridization Chain Reaction and Protein-Binding Amplification for Long-Term Imaging of Intracellular mRNA: Avoiding Signal Fluctuation

Yibo Zhou, Huiqiu Shi, Xinchao Xia, Sheng Yang, Junbin Li, Zhihe Qing, Jing Zheng and Ronghua Yang

Anal. Chem., 2024, 96, 11061
DOI: 10.1021/acs.analchem.4c01992

Integrated cell membrane encapsulated PQDs-TK quantum dot nanoclusters with ROS-responsive triggering for efficient and visualized DNA delivery

Tiange Wang, Yanlin Sun, Dong Zeng, Mengying Wang, Yajing Zhang, Gang Liu, Xin Chen and Liang Liu

Journal of Colloid and Interface Science, 2025, 683, 393
DOI: 10.1016/j.jcis.2024.12.159

Hurdles to healing: Overcoming cellular barriers for viral and nonviral gene therapy

Steffen Honrath, Michael Burger and Jean-Christophe Leroux

International Journal of Pharmaceutics, 2025, 674, 125470
DOI: 10.1016/j.ijpharm.2025.125470

Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness, Transfection Efficiency, and Biocompatibility

Mustafa Kotmakci, Natalia Toncheva-Moncheva, Sahar Tarkavannezhad, Bilge Debelec Butuner, Ivaylo Dimitrov and Stanislav Rangelov

Pharmaceutics, 2025, 17, 1012
DOI: 10.3390/pharmaceutics17081012

Nano Approaches to Nucleic Acid Delivery: Barriers, Solutions, and Current Landscape

Joan Castaneda Gonzalez, Ki Wan Park, Dallin Brian Evans, Rishi Sharma, Om Sahaym, Shamila Gopalakrishnan, Aqib Iqbal dar, Tulio A. Valdez and Anjali Sharma

WIREs Nanomed Nanobiotechnol, 2025, 17
DOI: 10.1002/wnan.70010

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ke Ma, Ke‐Zheng Chen and Sheng‐Lin Qiao

The Chemical Record, 2024, 24
DOI: 10.1002/tcr.202400010

Advancing mRNA vaccines for infectious diseases: key components, innovations, and clinical progress

Sha Li, Lu Zheng, Jingyi Zhong and Xihui Gao

Essays in Biochemistry, 2025, 69
DOI: 10.1042/EBC20253009

Time course of fluorescent-labelled oligonucleotide accumulation in cells with the use of folate receptor-targeted cationic liposomes

E. V. Shmendel, O. V. Markov, M. A. Zenkova and M. A. Maslov

Biological Products. Prevention, Diagnosis, Treatment, 2024, 24, 188
DOI: 10.30895/2221-996X-2024-24-2-188-199

Dual-Accelerated Signal Amplification in Biosensing via Spatial Confining Catalytic Hairpin Assembly-Activated Spherical CRISPR/Cas12a System for Trans-Cleavage of Hairpin DNA Reporters

Zhuqi Sui, Baoqiang Chen, Jia Zhao, Haidong Yang, Longhua Guo and Jianguo Xu

Anal. Chem., 2025, 97, 4668
DOI: 10.1021/acs.analchem.4c07111

Emerging dendrimer-based RNA delivery strategies

Sneha Das, Bhavesha Chanchlani, Shishira P S, Varshini Are and Swati Biswas

Nanomedicine, 2025, 20, 835
DOI: 10.1080/17435889.2025.2485023

Polymeric nanocarriers for therapeutic gene delivery

Jiayuan Zhang, Xinyu Yang, Zhichao Chang, Wenwei Zhu, Yuhua Ma and Haisheng He

Asian Journal of Pharmaceutical Sciences, 2025, 20, 101015
DOI: 10.1016/j.ajps.2025.101015

Delivery of mRNA Using Biomimetic Vectors: Progress and Challenges

Menghao Yin, Hanruo Sun, Yanan Li, Jingge Zhang, Jinjin Wang, Yan Liang and Kaixiang Zhang

Small, 2024, 20
DOI: 10.1002/smll.202402715

Polycations Improve Intracellular Stability of mRNA Delivered Using Lipid Nanoparticles for Prolonged Protein Expression

Jumpei Norimatsu, Rashida Hashim, Theofilus A. Tockary, Muhammad Shahid Nazir, Yuki Mochida and Satoshi Uchida

ACS Appl. Nano Mater., 2025, 8, 10898
DOI: 10.1021/acsanm.5c00633

Acid-triggered nucleic acid release from gold nanoparticles via Schiff base linkages: In vitro validation of endosomal escape and gene silencing

Ryosuke Hoshino, Katsura Sugawara, Kaori Terashita, Hiroki Shimamura, Jiro Toshima, Gen-ichiro Arimura and Yoshitsugu Akiyama

Biomaterials Advances, 2026, 178, 214477
DOI: 10.1016/j.bioadv.2025.214477

The Future of Nanomaterials Tackling the Challenge of Delivering Nucleic Acids to the Retina

José Hurst, Friederike Adams and Sven Schnichels

Adv Funct Materials, 2025, 35
DOI: 10.1002/adfm.202407173

PROTACs coupled with oligonucleotides to tackle the undruggable

Guangshuai Zhang, Si Yan, Yan Liu, Ziwei Du, Qin Min and Shuanglin Qin

Bioanalysis, 2025, 17, 261
DOI: 10.1080/17576180.2025.2459528

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti and Thomas Scheibel

Adv Healthcare Materials, 2025
DOI: 10.1002/adhm.202501886

Recent advances in drug delivery systems for pulmonary fibrosis therapy

Yan Yu, Cailing Gan, Kun Shi, Zhongwu Bei, Yang Yu, Meng Pan, Hanzhi Deng and Zhiyong Qian

Chinese Chemical Letters, 2025, 111596
DOI: 10.1016/j.cclet.2025.111596

Effective RNA Complexation by [2]Catenanes Confers Enhanced Resistance to Enzymatic Degradation

Dimitri Delcourt, José García Coll, Fabien B. L. Cougnon and Sébastien Ulrich

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202501631

Synthesis of Thermoresponsive Chitosan-graft-Poly(N-isopropylacrylamide) Hybrid Copolymer and Its Complexation with DNA

Marius-Mihai Zaharia, Florin Bucatariu, Maria Karayianni, Elena-Daniela Lotos, Marcela Mihai and Stergios Pispas

Polymers, 2024, 16, 1315
DOI: 10.3390/polym16101315

mRNA vaccines against HIV: Hopes and challenges

Akmal Zubair, Hanbal Ahmad, Muhammad Muaz Arif and Muhammad Ali

HIV Medicine, 2025, 26, 824
DOI: 10.1111/hiv.70024

Investigating the stability of RNA-lipid nanoparticles in biological fluids: Unveiling its crucial role for understanding LNP performance

Heyang Zhang and Matthias Barz

Journal of Controlled Release, 2025, 381, 113559
DOI: 10.1016/j.jconrel.2025.02.055

Topical delivery of siRNA to psoriatic skin model using high molecular weight chitosan derivatives: In vitro and in vivo studies

André Miguel Martinez Junior, Thalles Fernando Rocha Ruiz, Patrícia Simone Leite Vilamaior, Vera Aparecida de Oliveira Tiera, Sebastião Roberto Taboga and Marcio José Tiera

Drug Deliv. and Transl. Res., 2025, 15, 3199
DOI: 10.1007/s13346-025-01800-4

Aptamer based immunotherapy: a potential solid tumor therapeutic

Sarmilah Mathavan, Yew Joon Tam, Khairul Mohd Fadzli Mustaffa and Gee Jun Tye

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1536569

Immune Modulation with Oral DNA/RNA Nanoparticles

Ulpan Kart, Aigul Raimbekova, Sergey Yegorov and Gonzalo Hortelano

Pharmaceutics, 2025, 17, 609
DOI: 10.3390/pharmaceutics17050609

Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis

Xiao Xiao, Sheng Yang, Ge Jiang and Shisheng He

Nanomedicine, 2025, 20, 439
DOI: 10.1080/17435889.2025.2457781

Xeno Nucleic Acids as Functional Materials: From Biophysical Properties to Application

Tianyuan Bian, Yufeng Pei, Shitao Gao, Songtao Zhou, Xinyu Sun, Mingdong Dong and Jie Song

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401207

From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules

Cíntia Marques, Alexandre Porcello, Marco Cerrano, Farid Hadjab, Michèle Chemali, Kelly Lourenço, Basste Hadjab, Wassim Raffoul, Lee Ann Applegate and Alexis E. Laurent

Biomolecules, 2025, 15, 148
DOI: 10.3390/biom15010148

The role of micro-ribonucleic acid and small interfering-ribonucleic acid in precision nutrition for obesity management

Wardina Humayrah, Nindy Sabrina, Megah Stefani, Nurpudji Astuti Taslim, Reggie Surya, Matthew Nathaniel Handoko, Vincent Lau, Hardinsyah Hardinsyah, Trina Ekawati Tallei, Rony Abdi Syahputra and Fahrul Nurkolis

Clinical Nutrition ESPEN, 2025, 67, 463
DOI: 10.1016/j.clnesp.2025.03.049

Branched ligand-functionalized immuno-evasive PEGylation (BLIP) platform: Breaking through accelerated blood clearance and chemoresistance barriers with dual-targeting RNAi-chemotherapy synergy

Mengyang Liu, Ruijuan Xing, Ge Chen, Yuxiang Liang, Lu Huang, Yumeng Xi, Yue Li, Shifei Zhang, Yanan Sun, Yupin Song, Jintao Hao, Kexin Cong, Chaoxing He, Shaokun Yang, Lei Wang, Yihui Deng, Bai Xiang and Lei Wang

Chemical Engineering Journal, 2025, 522, 167098
DOI: 10.1016/j.cej.2025.167098

Photo‐Cross‐linked DNA Structures Greatly Improves Their Serum Nuclease Resistances and Gene Knock‐In Efficiencies

Zhigang Li, Youwei Ma, Chengxu Li, Shiyan Xiao and Haojun Liang

Small Methods, 2025, 9
DOI: 10.1002/smtd.202401346

Research Progress on Polymer-Based Nanocarriers for Tumor-Targeted Delivery of Survivin siRNA

Luya Ren, Shaoxia Wang, Bin-Chun Li and Guo-Bin Ding

Polymers, 2025, 17, 2279
DOI: 10.3390/polym17172279

Chitosan polyplexes for targeted gene delivery: From mechanisms to clinical applications

Radhika Joshi, Tripti Paliwal, Swapnil Sharma, Devesh U. Kapoor and Bhupendra G. Prajapati

Carbohydrate Polymers, 2025, 368, 124080
DOI: 10.1016/j.carbpol.2025.124080

Nanoscale synthetic biology with innovative medicinal applications

Jingsen Ji, Longsong Li, Weisheng Guo, Jing Zhang, Yuying Yao, Haoting Chen, Fangling Liao, Zhaokui Jin, Lu Liu, Jiang Ouyang and Xing-Jie Liang

Fundamental Research, 2024
DOI: 10.1016/j.fmre.2024.11.006