Symmetrical di-substituted phenylamino-s-triazine derivatives as anticancer agents: in vitro and in silico approach

Em Canh Pham, Bich-Ngoc Thi Le, Anh Minh Ngo, Long Binh Vong and Tuyen Ngoc Truong

RSC Adv., 2025, 15, 9968
DOI: 10.1039/D4RA08508F

Synthesis, evaluation of in vitro cytotoxic activity, and in silico studies of some 3-methylenamino-4(3H)-quinazolone derivatives

Tuyen Ngoc Truong, Em Canh Pham, Ngoc-Vi Nguyen Tran, Phu Thien Tieu, My Hanh Thi Cao, Tuoi Thi Hong Do and Khanh N. B. Le

RSC Adv., 2025, 15, 29864
DOI: 10.1039/D5RA03933A

Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents

Navid Dastyafteh, Manica Negahdaripour, Mohammad Hosein Sayahi, Mina Emami, Younes Ghasemi, Elham Safaei, Homa Azizian, Zahra Pakrouh Jahromi, Mehdi Asadi, Mohammad Reza Mohajeri-Tehrani, Fateme Zare, Minoo Shahidi, Zahra Pooraskari, Sayed Mahmoud Sajjadi-Jazi, Bagher Larijani, Mohammad Mahdavi and Sara Ranjbar

RSC Adv., 2024, 14, 35323
DOI: 10.1039/D4RA04492D

N,2,6-Trisubstituted 1H-benzimidazole derivatives as a new scaffold of antimicrobial and anticancer agents: design, synthesis, in vitro evaluation, and in silico studies

Em Canh Pham, Tuong Vi Le Thi, Huong Ha Ly Hong, Bich Ngoc Vo Thi, Long B. Vong, Thao Thanh Vu, Duy Duc Vo, Ngoc Vi Tran Nguyen, Khanh Nguyen Bao Le and Tuyen Ngoc Truong

RSC Adv., 2023, 13, 399
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Evaluation of in silico anticancer activity of bioactive compounds of black ginger as VEGFR2 inhibitors

Tran Trung Trinh Tran Trung Trinh, Le Thi Tuong Vi Le Thi Tuong Vi, Vo Thi Bich Ngoc Vo Thi Bich Ngoc, Ly Hong Huong Ha Ly Hong Huong Ha and Pham Canh Em Pham Canh Em

HIUJS, 2024, 27
DOI: 10.59294/HIUJS.VOL.6.2024.626

Sodium fluoride-assisted, solvent-controlled regioselective synthesis of 2-substituted and 1,2-disubstituted benzimidazoles with diverse substituents, and unveiling mechanistic insights

C.G. Arya, Munugala Chandrakanth, K. Fabitha, Neethu Mariam Thomas, Bhargava Sai Allaka, Srinivas Basavoju, Sonyanaik Banoth and Janardhan Banothu

Journal of Molecular Structure, 2024, 1306, 137935
DOI: 10.1016/j.molstruc.2024.137935

Anticancer activity of phytocompounds of black ginger (Kaempferia parviflora Wall. Ex Baker): In silico approach

Em Canh Pham and Huong Ha Ly Hong

Chemical Physics Impact, 2025, 11, 100903
DOI: 10.1016/j.chphi.2025.100903

Review of synthesis process of nitrobenzimidazole derivatives

Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif and Hamid Sdassi

Synthetic Communications, 2024, 54, 167
DOI: 10.1080/00397911.2023.2291515

REVOLUTIONIZING ANTIMICROBIAL DRUG DISCOVERY: COMPUTATIONAL DESIGN AND ADMET STUDIES OF EMERGING POTENT ANTI-MICROBIAL AGENTS

MADHURITA CHAKRABARTI

Int J Pharm Pharm Sci, 2023, 28
DOI: 10.22159/ijpps.2023v15i8.48526

Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors

Em Canh Pham and Tuyen Ngoc Truong

ACS Omega, 2022, 7, 33614
DOI: 10.1021/acsomega.2c05206

Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1H-benzimidazole Derivatives as Antiproliferative, Antifungal, and Antibacterial Agents

Ngoc-Kim-Ngan Phan, Thi-Kim-Chi Huynh, Hoang-Phuc Nguyen, Quoc-Tuan Le, Thi-Cam-Thu Nguyen, Kim-Khanh-Huy Ngo, Thi-Hong-An Nguyen, Khoa Anh Ton, Khac-Minh Thai and Thi-Kim-Dung Hoang

ACS Omega, 2023, 8, 28733
DOI: 10.1021/acsomega.3c03530

Evaluation of in silico anticancer activity of some striazine derivatives as VEGFR2 inhibitors

Le Thi Tuong Vi Le Thi Tuong Vi, Pham Canh Em Pham Canh Em and Truong Ngoc Tuyen Truong Ngoc Tuyen

HIUJS, 2023, 19
DOI: 10.59294/HIUJS.VOL.5.2023.545

In vivo and in silico antihypertensive, anti-inflammatory, and analgesic activities of Vernonia amygdalina Del. leaf extracts

Em Canh Pham, Vien Van Doan, Tuong Vi Le Thi, Cuong Van Ngo and Lenh Vo Van

Heliyon, 2024, 10, e38634
DOI: 10.1016/j.heliyon.2024.e38634

Synthesis, crystal structure, and antimicrobial evaluation of novel 4-oxyquinazoline derivatives containing a benzimidazole moiety

Ya Yan, Songsong Liu, Lian An, Yehui Yang, Guangmin Tian and Xiaoping Bao

Journal of Molecular Structure, 2024, 1303, 137611
DOI: 10.1016/j.molstruc.2024.137611

Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry

Sasadhar Majhi

CTMC, 2025, 25, 63
DOI: 10.2174/0115680266311149240822111827

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Leqaa A. Mohammed, Mohammed Alwan Farhan, Safaa A. Dadoosh, Mustafa A. Alheety, Abdulwahhab H. Majeed, Ali Saadon Mahmood and Zaid H. Mahmoud

SynOpen, 2023, 07, 652
DOI: 10.1055/a-2155-9125

Benzimidazole Derivatives in Breast Cancer: Target-Specific Therapeutic Breakthroughs

S Mounika, Hemalatha K, Rohit Pal, Gurubasavaraja Swamy Purawarga Matada, Pradan P Jain, Haripriya E, Md. Ashadul Sk and Viji M P

CTMC, 2025, 25, 1629
DOI: 10.2174/0115680266336395241115092048

Synthesis and Anti-Ovarian Cancer Effects of Benzimidazole-2-Substituted Pyridine and Phenyl Propenone Derivatives

A-Long Cui, Zi-Ying Zhou, Ya-Li Wang, Lin-Tao Wu, Si-Tu Xue and Zhuo-Rong Li

Future Med. Chem., 2022, 14, 1835
DOI: 10.4155/fmc-2022-0244

Diaryl-substituted benzimidazole derivatives as antiproliferative agents: Design, synthesis, in vitro activity, and SAR analysis

Sule Gursoy and Ronak Haj Ersan

Journal of Molecular Structure, 2024, 1308, 137960
DOI: 10.1016/j.molstruc.2024.137960

Antiproliferative and antimicrobial studies of novel organic-inorganic nanohybrids of ethyl 2-((5-methoxy-1H-benzo[d]imidazol-2-yl)thio)acetate (EMBIA) with TiO2 and ZnO

Nuaman F. Alheety, Leqaa A. Mohammed, Abdulwahhab H. Majeed, Ali Aydin, Khalid Dfeek Ahmed, Mustafa A. Alheety, Manaf A. Guma and Sushil Dohare

Journal of Molecular Structure, 2023, 1274, 134489
DOI: 10.1016/j.molstruc.2022.134489

A Review on Functionalization of Benzo‐5,6‐Fused Bicyclic Heteroaromatic Compounds

Marappan Pradeep Kumar, Aksa S Annie, Vikash Kumar Bind, Ramesh Adithya, P. Amaladass and Vasudevan Dhayalan

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400455

Solvent-free strategy for facile synthesis and cytotoxicity evaluation of benzimidazole derivatives

Hue Thi Buu Bui, Kiep Minh Do, Quang Vinh Hong, Hieu Trong Le, Saw Yu Yu Hnin, De Quang Tran, Hieu Van Mai, Thao Thi Thach Nguyen, Trang Thi Kieu Mai and Hiroyuki Morita

Tetrahedron, 2024, 156, 133940
DOI: 10.1016/j.tet.2024.133940

Evaluation of in silico antidiabetic activity of phytocompounds of wild bitter gourd on DPP4 target

Nguyen Ly Doan Trang Nguyen Ly Doan Trang, Luong Thi Thuong Luong Thi Thuong, Nguyen Thuy Dan Ly Nguyen Thuy Dan Ly, Nguyen Thi Ngoc Anh Nguyen Thi Ngoc Anh, Nguyen Quoc Trung Nguyen Quoc Trung, Nguyen Huynh My Trinh Nguyen Huynh My Trinh and Pham Canh Em Pham Canh Em

HIUJS, 2024, 37
DOI: 10.59294/HIUJS.VOL.6.2024.627

Regio- and chemoselective synthesis of new isoxazolyl-linked benzimidazolones via 1,3-dipolar cycloaddition: Characterization, corrosion studies, density functional theory, and Monte Carlo simulations

Walid Ettahiri, Mohamed Adardour, Elhachmia Ech-chihbi, Samira Dalbouha, Belkheir Hammouti, Zakia Rais, Abdesselam Baouid and Mustapha Taleb

Fuel, 2024, 371, 132058
DOI: 10.1016/j.fuel.2024.132058

Spectroscopic characterization, DFT calculations, antimicrobial activity, and molecular docking studies of 5-methoxy-1H-benzo[d]imidazole and its Ag(I) complex

Ceyhun Kucuk, Sibel Celik, Senay Yurdakul and Belgin Erdem

Polyhedron, 2024, 251, 116868
DOI: 10.1016/j.poly.2024.116868

Benzimidazole‐Containing Compounds as Anticancer Agents

Ulviye Acar Çevik, Ayşen Işik, Betül Kaya, Ravikumar Kapavarapu, Mithun Rudrapal, Gresa Halimi, Abdüllatif Karakaya, Zahra Maryam, İsmail Celik, Asaf Evrim Evren, Hakan Ünver, Emine Rana Bagci, Merve Yildirim, Yusuf Özkay and Zafer Asım Kaplancikli

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202401566

Immobilization of Ni nanoparticles on pyridine-functionalized MWCNTs for indirect synthesis of benzimidazoles and quinazolinones, and their molecular docking studies as effective inhibitors of α-glucosidase

Fatemeh Mirzaeian, Hossein Sabet-Sarvestani and Hossein Eshghi

Journal of Molecular Structure, 2025, 1319, 139508
DOI: 10.1016/j.molstruc.2024.139508

Facile Synthesis of 1,2-Disubstituted Benzimidazoles as Potent Cytotoxic Agents

Hue Thi Buu Bui, Zin Paing Htoo, Quang Vinh Hong, Hieu Trong Le, De Quang Tran, Saw Yu Yu Hnin, Kiep Minh Do and Hiroyuki Morita

Chem. Pharm. Bull., 2024, 72, 944
DOI: 10.1248/cpb.c24-00570

Synthesis, crystal structure, theoretical calculations, linear and nonlinear optical response of new 2-(thiophen-3-ylmethyl)-1h-benzo[d]imidazole ligand and its binuclear copper complex

Raziqa Djaafer-Moussa, Lakhemici Kaboub, Meriem Zaidi, Layachi Merabet, Fabrice Pointillart, Fatima Setifi, Abelkrim Gouasmia, Nour El Houda Loucif and Douniazed Hannachi

Journal of Molecular Structure, 2025, 1345, 143154
DOI: 10.1016/j.molstruc.2025.143154

Formulation development, optimization, in vivo antidiabetic effect and acute toxicity of directly compressible herbal tablets containing Merremia tridentata (L.) extract

Em Canh Pham, Lenh Vo Van, Cuong Viet Nguyen, Ngoc Thoi Nguyen Duong and Tuong Vi Le Thi

Journal of Drug Delivery Science and Technology, 2023, 84, 104445
DOI: 10.1016/j.jddst.2023.104445

Đánh giá hoạt tính kháng khuẩn, kháng nấm của cao chiết quả Khổ qua rừng (Momordica charantia L. Var. Abbreviata ser.) thu hái ở tỉnh Bến Tre, Việt Nam

Võ Thị Bích Ngọc Võ Thị Bích Ngọc, Lê Thị Tường Vi Lê Thị Tường Vi, Trần Trung Trĩnh Trần Trung Trĩnh, Lý Hồng Hương Hạ Lý Hồng Hương Hạ and Phạm Cảnh Em Phạm Cảnh Em

HIUJS, 2023, 43
DOI: 10.59294/HIUJS.26.2023.525

Molecular docking study of anticancer activity of some s-triazine derivatives as HDAC6 inhibitors

Phạm Cảnh Em Phạm Cảnh Em, Lê Thị Tường Vi Lê Thị Tường Vi and Trương Ngọc Tuyền Trương Ngọc Tuyền

HIUJS, 2023, 1
DOI: 10.59294/HIUJS.VOL.5.2023.543