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Base-controlled diastereoselective [3+2]-cycloaddition and Michael addition of isatin ketonitrones and chalcones to construct spiropyrrolidine oxoindoles and γ-substituted isatin ketonitrones

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Synthesis of thiopyran derivatives via [4 + 2] cycloaddition reactions

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Highly regio- and stereoselective (3 + 2) annulation reaction of allenoates with 3-methyleneindolin-2-ones catalyzed by a planar chiral [2.2]paracyclophane-based bifunctional phosphine–phenol catalyst

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Org. Biomol. Chem., 2024, 22, 7817
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Recent progress in the electrochemical selenofunctionalization of alkenes and alkynes

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Green Chem., 2023, 25, 7485
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DABCO-promoted highly diastereo- and regioselective construction of C-3 functionalized spirooxindoles via [3 + 2] cycloaddition of 2-aryl/heteroarylidene-1H-indene-1,3(2H)-diones with N-2,2,2-trifluoroethylisatin ketimines at ambient conditions

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Visible-light-induced organophotocatalytic and singlet oxygen-initiated domino construction of 1,4-dihydropyridines, C-3 functionalized spiro[indoline-3,4′-pyridines] and C-11 functionalized spiro[indeno-[1,2-b]quinoxaline-11,4′-pyridines]

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Org. Biomol. Chem., 2023, 21, 1518
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Highly enantio-selective synthesis of aza-spirocyclic indanones via rhodium catalysis

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Org. Biomol. Chem., 2025, 23, 3542
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Copper-catalyzed desymmetric silylative-cyclization of 1,6-diynes for synthesis of spirocyclic compounds

Cui-Cui Shan, Zi-Lu Wang and Yun-He Xu

Org. Chem. Front., 2024, 11, 1211
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Chiral synthetic unprecedented spiro[indoline-2,3′-thiophen]-3-ones via an organocatalytic asymmetric sulfa-Michael/aldol cascade reaction

Mao Zhang, Xing-Hai Fei, Gui-Ping Yang, Cheng Lin, Wen-Jie Li, Ming-Liang Rao, Meng Zhou, Chong Zhao, Bin He and Yong-Long Zhao

Org. Chem. Front., 2024, 11, 6426
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Design, synthesis, and apoptotic evaluation of spiro[indoline-3,3′-pyrazolo[1,2-a]indazole] derivatives via [3 + 2] N,N-cycloaddition

Rapeti Thrinadh Kumar, Sohel C. Mulani, Shaik Anwar and Ravi K. Kottalanka

Org. Biomol. Chem., 2025, 23, 3583
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Stereoselective synthesis of CF3-containing spirocyclic-oxindoles using N-2,2,2-trifluoroethylisatin ketimines: an update

Biplob Borah, Naveena S. Veeranagaiah, Samrita Sharma, Mihir Patat, Madavi S. Prasad, Raghavaiah Pallepogu and L. Raju Chowhan

RSC Adv., 2023, 13, 7063
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Direct synthesis of spirooxindoles enabled by palladium-catalyzed allylic alkylation and DBU-mediated cyclization: concept, scope and applications

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Org. Chem. Front., 2024, 11, 5443
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Constructing spirooxindoles from non-oxindole precursors: a one-pot nitro-reduction/double lactamization approach to spiro[indoline-3,3′-quinoline]-2,2′-diones

Raju Chouhan, Abhijit Gogoi and Sajal Kumar Das

Org. Biomol. Chem., 2024, 22, 7601
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Synthesis of triazole-fused tetracyclic spirooxindole derivatives via metal-free Huisgen cycloaddition

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Chem. Commun., 2024, 60, 10009
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Exploring pharmacokinetics of some spiropyrrolizine-oxindoles as SLC10A1 inhibitors: Eco-friendly regioselective synthesis, DFT, molecular docking, and molecular dynamics simulation approach

Shubham Dashora, Tulika Bhardwaj, Anirban Chowdhury, Dhruvisha K. Patel, Pijush De, Harlal Singh, Srinu Tothadi, Pallavi Somvanshi and Keshav Lalit Ameta

Journal of Molecular Structure, 2026, 1349, 143749
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New spirooxindole-benzothiazole hybrids incorporating a trifluoromethyl moiety as antiviral agents: Design, synthesis, crystal structure analysis, and in silico studies

Asu Busra Temizer-Keser, Görkem Güngör, Suzanne Kaptein, Dirk Jochmans, Mehmet Özbil, Filiz Betül Kaynak, Johan Neyts and Nilgün Karalı

Journal of Molecular Structure, 2025, 144093
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Visible‐Light‐Mediated Direct Expeditious Photochemical Construction of Spirocyclic‐Oxindoles

Biplob Borah, Samrita Sharma and L. Raju Chowhan

Asian J Org Chem, 2023, 12
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Enantioselective formal total synthesis of dihydrospirotryprostatin B

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Journal of Asian Natural Products Research, 2024, 26, 1175
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Organocatalytic Asymmetric [4 + 2]-Cycloadditions of 2-Aminophenyl Enones with Isatin-Derived Ketimines: Diastereo- and Enantioselective Synthesis of Spirooxindole-Tetrahydroquinazolines

Ji Won Han, Yoseop Kim and Sung-Gon Kim

Org. Lett., 2024, 26, 252
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Quantitative structure-activity relationship and ADME prediction studies on series of spirooxindoles derivatives for anti-cancer activity against colon cancer cell line HCT-116

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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

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Molecules, 2023, 28, 618
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Multicomponent Direct Assembly of N-Heterospirocycles Facilitated by Visible-Light-Driven Photocatalysis

Oliver M. Griffiths and Steven V. Ley

J. Org. Chem., 2022, 87, 13204
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Synthesis of C–N or C–C Spiroindolines via Rearrangement Coupling Reaction

Xiaoling Liu, Panpan Qiao, Hui Chen, Yu Gao and Haijun Chen

Org. Lett., 2024, 26, 9759
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Superacid-Promoted synthesis of spirooxindoles

Jacob C. Hood, Hien Vuong and Douglas A. Klumpp

Tetrahedron Letters, 2023, 132, 154817
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Enantioselective Synthesis of Spirooxindole Derivatives through Lewis Acid-Catalyzed Michael Addition/Cyclization Cascade

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J. Org. Chem., 2025, 90, 13303
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Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

Hua Zhao and Yufen Zhao

Molecules, 2023, 28, 6488
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C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)

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Bioorganic Chemistry, 2024, 143, 107091
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Pd-Catalyzed Asymmetric Intramolecular Dearomatizing Reductive Heck Reaction of Indoles

Bi Wang, Jing-Kun Gao, Shuo Sun, Zhen-Lu Shen, Yun-Fang Yang, Ren-Xiao Liang and Yi-Xia Jia

Org. Lett., 2024, 26, 3739
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Synthesis of some bioactive materials derived from 4-aminotetrahydropyran

Salwa A. Jabbar and Ghasaq S. Mustafa

Materials Today: Proceedings, 2023
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Dipolarophile-Controlled Regioselective 1,3-Dipolar Cycloaddition: A Switchable Divergent Access to Functionalized N-Fused Pyrrolidinyl Spirooxindoles

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IJMS, 2023, 24, 3771
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Michael Addition/Hemiketalization Cascade Reaction Between β-Dicarbonyl Compounds and Isatin-Derived α,β-Unsaturated Ketones to Construct 3,4'-Pyran-spirooxindoles

Mingmei Zhang, Feng Sha and Xin-Yan Wu

Chinese Journal of Organic Chemistry, 2025, 45, 1369
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A Sulfonic Acid Polyvinyl Pyridinium Ionic Liquid Catalyzes the Multi-Component Synthesis of Spiro-indoline-3,5′-pyrano[2,3-d]-pyrimidines and -Pyrazines

Mehdi Khalaj, Mahboubeh Taherkhani, Leo Payen and Axel Klein

Molecules, 2023, 28, 3663
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Domino Transformations of 3‐Fluoro‐1,2,4‐Triazine Derivatives towards Spirocyclic and Fused Pyridines

Anthony Lapray, Thomas Martzel, Marie‐Aude Hiebel, Sylvain Oudeyer, Franck Suzenet and Jean‐François Brière

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One-pot synthesis, structural study, in silico and in vitro anticancer evaluation of spiropyrrolidine oxindoles obtained by the 3-CR of isatin, benzyl amine and a thiazolo[3,2-a]indole derivative

C.B. Meenakshy, Athul Sudheendranath, Noble V. Thomas, V. S Asha, P.G. Biju and Ani Deepthi

Journal of Molecular Structure, 2024, 1298, 137026
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One-pot synthesis and characterization of spirooxindole-3,4'-pyran derivatives via FeCl3-Catalyzed multicomponent reaction: A facile approach with high yields and eco-friendly methodology

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Journal of the Indian Chemical Society, 2025, 102, 101673
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Domino Reactions through Recursive Anionic Cascades: The Advantageous Use of Nitronates

Saumitra Sengupta, Srihari Pabbaraja and Goverdhan Mehta

Eur J Org Chem, 2022, 2022
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Microwave-assisted synthesis of pyrrolidinyl-spirooxindoles via tandem 1,3-dipolar cycloaddition and oxidative dehydrogenation

Hong-bo Tan, Yu-heng Xiang, Jing-wen Huang, Si-ying Ren, Chang-qiu Lin, Zhi-gang Xu, Dian-yong Tang and Zhong-zhu Chen

Tetrahedron, 2025, 169, 134379
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Concise route to stereoselective chlorobenzene-based spiropyrrolidine oxindoles for pursuit as antitubercular agents

Madhuri P Rao, Anu Chauhan, Lucia Pintilie, Sudheer Kumar Singh and Madhu Ganesh

J Chem Sci, 2023, 135
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Molecular Diversity of Base Promoted Annulation of MBH Carbonates of Isatins and Dialkyl But‐2‐ynedioates

Ting Tang, Xue‐Yan Liu, Jing Sun and Chao‐Guo Yan

ChemistrySelect, 2023, 8
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Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction

Ziying Xiao, Fengshun Xu, Jing Sun and Chao-Guo Yan

Beilstein J. Org. Chem., 2023, 19, 1234
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Base Promoted Three‐component Reaction for Efficient Construction of Spiro[indoline‐3,3′‐quinoline]‐2,5′‐dione

Ping Wu, Feng‐Shun Xu, Jing Sun and Chao‐Guo Yan

ChemistrySelect, 2023, 8
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Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis

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Antibiotics, 2025, 14, 595
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Convenient Synthetic Protocols for Diverse Functionalized Dihydrobenzofuran-Fused Spiro-indanedione-oxindole Scaffolds

Jing Sun, Xueyan Liu, Qiu Sun, Ying Han and Chao-Guo Yan

J. Org. Chem., 2023, 88, 11562
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Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles

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Base-promoted [3+2]-cycloaddition of N-alkoxy-4-oxo-acrylamides with isatins for stereoselective synthesis of spirooxindole-2-oxazolidinones

Yeongju Kim and Sung-Gon Kim

Tetrahedron Letters, 2025, 164, 155624
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Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles

Jie Liu, Shubhadip Mallick, Yusheng Xie, Corentin Grassin, Belén Lucas, Beate Schölermann, Axel Pahl, Rebecca Scheel, Carsten Strohmann, Christoph Protzel, Thorsten Berg, Christian Merten, Slava Ziegler and Herbert Waldmann

Angew Chem Int Ed, 2023, 62
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A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR

Ehab S. Gad, Salem S. Salem, Samy Selim, Mohammed S. Almuhayawi, Mohammed H. Alruhaili, Soad K. Al Jaouni, Amna A. Saddiq, Medhat E. Owda and Chinnaperumal Kamaraj

PLoS ONE, 2025, 20, e0319791
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Construction of C2‐Spirocyclopropyl‐Indolin‐3‐Ones through Base‐Promoted [2+1] Annulation Reaction of Indolin‐3‐ones with Bromosulfonium Salts

Mao Zhang, Fenfen Yang, Xiang Guan, Mingshan Shuai, Qingqing Zhang, Xiaozhong Fu, Yuanyong Yang, Meng Zhou, Bin He and Yonglong Zhao

Eur J Org Chem, 2023, 26
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Qualitative and quantitative determination of total phenols in Achillea tenuifolia lam

Niran A. Al-Ogaili, Ibrahim S. Al-Jaboury and Zainab Yaseen Mohammed Hasan

Results in Chemistry, 2023, 5, 100931
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Novel hydroquinazoline derivatives from Schiff base and study their biological activity

Mohammed Khalaf Auaed and Ayad Suleiman Hamad

Materials Today: Proceedings, 2023
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Substrate-Controlled Diastereo- and Enantiodivergent Synthesis of Bis-Spirocyclopropyloxindoles from Available Isatin as a Single Starting Material

Mehdi Eskandari, Khosrow Jadidi and Behrouz Notash

J. Org. Chem., 2023, 88, 5254
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An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds

Daqian Wang, Jing Sun, Ying Han, Qiu Sun and Chao-Guo Yan

Org. Lett., 2022, 24, 7790
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Metal-free Oxidative Spirocyclization of Pyrrole-2-carboxamides

Yulei Zhao, Xiaotong Dong, Zhiwei Zhang, Jiale Li, Jia Zhou and Jingran Liu

J. Org. Chem., 2025, 90, 12717
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