Cynarin protects against seizures and neuronal death in a rat model of kainic acid-induced seizures

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Food Funct., 2025, 16, 3048
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Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke

Yu Li, Jing Zhang, Yuxin Lei, Mengli Chang, Jing Xu and Shihuan Tang

Journal of Ethnopharmacology, 2025, 343, 119435
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Reduction in presynaptic glutamate release and the prevention of glutamate excitotoxicity by lupeol in rats

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Neurochemistry International, 2025, 185, 105951
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Inhibitory regulation of glutamate release from rat cortical nerve terminals by thymoquinone

Mao-Hsiang Hsiao, Kun‑Chieh Yeh, Ming-Yi Lee, Wei-Che Chiu and Su-Jane Wang

NeuroToxicology, 2025, 111, 103329
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Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF-κB signaling axis after spinal cord injury

Ruyi Zhu, Yaling Zhang, Weitai He, Yanan Sun, Xin Zhao, Yaping Yan and Qian Zhang

European Journal of Pharmacology, 2024, 973, 176566
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Rutin alleviates Pb-induced oxidative stress, inflammation and cell death via activating Nrf2/ARE system in SH-SY5Y cells

Fen Li, Lin Zhang, Xingxu Zhang, Qimeng Fang, Yingshun Xu and Hui Wang

NeuroToxicology, 2024, 104, 1
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The Ethanolic Extract of Polygala paniculata L. Blocks Panx1 Channels and Reduces Ischemic Brain Infarct in a Dose- and Sex-Dependent Way

Cristina Martins-Silva, Connor L. Anderson, Andrew K. J. Boyce, Tassiane E. S. Andrade, Tiago Tizziani, Kheytiany H. S. Lopes, Gustavo A. Micke, Sean P. Cregan, Adair Roberto Soares dos Santos and Roger J. Thompson

Mol Neurobiol, 2025, 62, 3258
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Epigoitrin decreases synaptosomal glutamate release and protects neurons from glutamate excitotoxicity in rats

Yi Chang, Wun-Jing Pan and Su-Jane Wang

European Journal of Pharmacology, 2025, 998, 177654
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Neuroprotective Effect of Rutin on Neurobehavioral Dysfunction and Cognitive Impairment-Induced by Methamphetamine in Male Rats

Mobina Gheibi, Somayeh Nazari, Mohammad Vahabzadeh-Kebria, Pooria Salehi Sangani, Elmira Beirami, Hamed Ghazvini, Raheleh Rafaiee, Rezvan Yazdian-Robati and Seyedeh Masoumeh Seyedhosseini Tamijani

Iran J Psychiatry Behav Sci, 2025, 19
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NRICM101 prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system

Chi-Feng Hung, Wei-Che Chiu, Jia-Cih Chen, Wu-Chang Chuang and Su-Jane Wang

International Immunopharmacology, 2024, 140, 112842
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Flavonoids as therapeutic agents for epilepsy: unveiling anti-inflammatory and antioxidant pathways for novel treatments

Ya Zhang, Xizhuo Hu and Li-Qun Zou

Front. Pharmacol., 2024, 15
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Inhibition of Synaptic Glutamate Exocytosis and Prevention of Glutamate Neurotoxicity by Eupatilin from Artemisia argyi in the Rat Cortex

Cheng-Wei Lu, Chia-Chan Wu, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin and Su-Jane Wang

IJMS, 2022, 23, 13406
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Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats

Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh and Su-Jane Wang

European Journal of Pharmacology, 2024, 963, 176280
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Analysis of the action mechanisms and targets of herbal anticonvulsants highlights opportunities for therapeutic engagement with refractory epilepsy

Sobia Tabassum, Susan Shorter and Saak V. Ovsepian

J Mol Med, 2024, 102, 761
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Role of astrocytes in the pathogenesis of perinatal brain injury

Ling Li, Xuewei Cui, Baoli Zhu, Lele Zhou, Yaya Guo, Tianjing Liu and Yongyan Shi

Mol Med, 2025, 31
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Rutin Ameliorates Toxoplasma gondii-Induced Brain Tissue Damage via Inhibiting P2X7R/NLRP3 Pro-Inflammatory and Enhancing PI3K/AKT/Nrf2/HO-1 Antioxidant Signaling Pathway

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Biol Bull Russ Acad Sci, 2024, 51, 1312
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Mangiferin depresses vesicular glutamate release in synaptosomes from the rat cerebral cortex by decreasing synapsin I phosphorylation

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European Journal of Pharmacology, 2023, 950, 175772
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Rutin mitigates acetic acid-induced ulcerative colitis: novel coloprotective mechanism

Iman O Sherif, Nora H Al-Shaalan and Walaa F Awadin

Toxicology Research, 2024, 13
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Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats

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Biomolecules, 2024, 14, 589
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Sodium Houttuyfonate Prevents Seizures and Neuronal Cell Loss by Maintaining Glutamatergic System Stability in Male Rats with Kainic Acid-Induced Seizures

Yi Chang, Yi-Jun Chen and Su-Jane Wang

Biomedicines, 2024, 12, 1312
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Flavonoids Derived from Chinese Medicine: Potential Neuroprotective Agents

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Am. J. Chin. Med., 2024, 52, 1613
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Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice

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JIR, 2025, Volume 18, 1235
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A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures

Shyam Sunder Rabidas, Chandra Prakash, Jyoti Tyagi, Jyoti Suryavanshi, Pavan Kumar, Jaydeep Bhattacharya and Deepak Sharma

Brain Sciences, 2023, 13, 102
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Neuroprotective effects of rutin in ischemic stroke: a review

Ali Mohammad Pourbagher-Shahri, Fatemeh Forouzanfar, Ehsan Saburi and Hanie Mahaki

Inflammopharmacol, 2025, 33, 4181
DOI: 10.1007/s10787-025-01861-4

Hydrogen inhalation exerts anti-seizure effects by preventing oxidative stress and inflammation in the hippocampus in a rat model of kainic acid-induced seizures

Tzu-Kang Lin, Ming-Shang Pai, Kun-Chieh Yeh, Chi-Feng Hung and Su-Jane Wang

Neurochemistry International, 2025, 183, 105925
DOI: 10.1016/j.neuint.2024.105925

Molecular mechanisms of neuroprotective effect of rutin

Zhang Chunmei and Wang Shuai

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1599167