Synergistic isoniazid-Mn(II) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy

Yan Miao; Jian An; Xufeng Liang; Boyong Su; Tingting Chen; Jin Wang; Yan Cai; Shajun Zhu; Yong Yao; Yang Wang

doi:10.1039/D5CC03099D

Synergistic isoniazid-Mn(ii) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy

Yan Miao,^a Jian An,^a Xufeng Liang,^a Boyong Su,*^b Tingting Chen,^a Jin Wang,^a Yan Cai,*^a Shajun Zhu,^c Yong Yao

*^a and Yang Wang

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China
E-mail: yancai2010@ntu.edu.cn, yaoyong1986@ntu.edu.cn, ywang85@ntu.edu.cn

^b School of Mechanical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China
E-mail: sby1872@163.com

^c Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226019, P. R. China

Abstract

An intelligent INH@ZIF@MnO₂/HA nanotherapeutic platform, ingeniously engineered to augment tumor-specific oxidative stress in chemodynamic therapy, effectively harnesses the isoniazid (INH)-mediated generation of highly reactive non-Fenton-type hydroxyl radicals (˙OH) catalyzed by Mn²⁺ ions.

Chemical Communications

Synergistic isoniazid-Mn(ii) mediated non-Fenton-type hydroxyl radical generation for amplifying tumor chemodynamic therapy

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