Issue 36, 2012
From the journal:

Chemical Communications

Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones†‡

Yan Zheng,a   Heng-Ying Xiong,a   Jing Nie,a   Ming-Qing Huaa  and  Jun-An Ma*a  

* Corresponding authors

a Department of Chemistry, Tianjin University, Tianjin 300072, China
E-mail: majun_an68@tju.edu.cn
Fax: +86-22-2740-3475

Abstract

We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)2AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.

Graphical abstract: Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

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Article information

DOI
https://doi.org/10.1039/C2CC30949A
Article type
Communication
Submitted
09 Feb 2012
Accepted
09 Mar 2012
First published
09 Mar 2012

Chem. Commun., 2012,48, 4308-4310

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Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones

Y. Zheng, H. Xiong, J. Nie, M. Hua and J. Ma, Chem. Commun., 2012, 48, 4308 DOI: 10.1039/C2CC30949A

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