Issue 1, 2012
From the journal:

Chemical Communications

Synthesis of 3-substituted 1,5-aldehyde estersvia an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals†‡

Jing Deng,a   Fei Wang,b   Wenzhong Yan,a   Jin Zhu,a   Hualiang Jiang,a   Wei Wang*ac  and  Jian Li*a  

* Corresponding authors

a School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: jianli@ecust.edu.cn
Fax: +86 21-64252584
Tel: +86 21-64252584

b Chinese Pharmacopoeia commission, Building 11, Fahua Nanli, Beijing, China

c Department of Chemistry and Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA
E-mail: wwang@unm.edu
Fax: +1 505-277-2609

Abstract

A highly enantioselective organocatalytic protocol for conjugate addition of new nucleophilic carbonylmethyl 2-pyridinylsulfone to enals has been developed in good yields and with high enantioselectivities. The resulting Michael adducts are versatile building blocks for a variety of organic transformations.

Graphical abstract: Synthesis of 3-substituted 1,5-aldehyde estersvia an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals

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Article information

DOI
https://doi.org/10.1039/C1CC15714K
Article type
Communication
Submitted
15 Sep 2011
Accepted
24 Oct 2011
First published
07 Nov 2011

Chem. Commun., 2012,48, 148-150

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Synthesis of 3-substituted 1,5-aldehyde estersvia an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals

J. Deng, F. Wang, W. Yan, J. Zhu, H. Jiang, W. Wang and J. Li, Chem. Commun., 2012, 48, 148 DOI: 10.1039/C1CC15714K

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