Diastereospecific cyclization of 3-arylidene-1-pyrrolinium salts containing an alkyltriarylphosphonium fragment: a path to the synthesis of new pyrrolizidine derivatives
Abstract
We report a diastereospecific method for the synthesis of phosphorus-containing pyrrolizidines based on the cyclization of 3-arylidene-1-pyrrolinium derivatives containing an alkyltriphenylphosphonium salt fragment catalyzed by sodium ethylate and water. A number of new phosphorus-containing pyrrolizidines were obtained with product yields reaching 99%. Experimental data were obtained, revealing the details of the mechanism of this reaction.