Themed collection 2026 Chinese New Year and Lunar New Year Collection: Chemistry-Biology Interface

Programmable DNA nanostructures enable stimuli-responsive drug delivery and multimodal biosensing. This review highlights their modular design, stability, and precision in disease-targeted therapy and early cancer diagnosis.

This review offers a concise overview of platinum-based anticancer complexes targeting the G-quadruplex, aiming to overcome cisplatin-resistance.

Peptide-based delivery systems advance mRNA therapies for protein replacement, gene editing, and vaccine development.

Allosteric regulation is a fundamental mechanism in enzyme function, enabling dynamic modulation of activity through ligand binding at sites distal to the active site.

The sydonol biosynthetic pathway was elucidated, featuring two novel enzymatic reactions: a bisabolene cyclase (Syd1) mediating 1,5-proton transfer and 1,7-hydride shift, and an unusual P450 (Syd2) catalyzing bisabolene aromatization.

Importance of experimental configurations for in vitro mechanical evaluation of microneedle arrays as the first-line investigation of skin insertion potential.

The enzyme inhibitory effect of aloin-Fe₃O₄@rGO nanocomposites and their anti-browning effect and safety.

Site-specific glycan conjugation enables a stable and efficacious biparatopic HER2-targeting ADC.

ZBTB20 binds to the afp and foxO1 promoters, represses their transcription, and regulates hepatocarcinogenesis.

Multidimensional structural and mechanistic analyses elucidate the molecular basis of chuangxinmycin's species-selective inhibition of bacterial tryptophanyl-tRNA synthetases.

An iridium(III) 3-chloro-6-thio-1,2,4,5-tetrazine complex was modified with an RGD peptide, affording a photoactive conjugate that specifically targeted tumour cells and showed enhanced emission and singlet oxygen generation upon photoirradiation.

Centrosomal localization of DLGAP5 mRNA, revealed by MERR APEX-seq, is mediated by nascent MBD1 polypeptides in the polysome during co-translational targeting.

GTB-DAS·2H₂O and GTB-DAS CM were comparatively investigated, and GTB-DAS·2H₂O shows superior stability, tabletability, and dissolution performance, making it a more promising and reliable solid form for the development of combinational therapy.

In this study, a nanoemulsion of a BCS class II drug, fenofibrate, was cross-linked via a Michael-type addition reaction to yield micro-crystalline Fen-embedded micro-hydrogels with tunable degradation.

Therapeutic proteins have drawn increasing attention in the development of advanced drugs and biomedical devices, yet there are outstanding challenges for the delivery of multiple-protein therapies with customized release profiles.

Epigallocatechin-3-gallate (EGCG) is a key bio-active component of green tea and has demonstrated significant antidepressant activity in laboratory animals.