We report two shunt pathways that expand our knowledge on the biosynthesis of the antibiotic pleuromutilin. Three new congeners of pleuromutilin were isolated, alongside the semi-synthesis of a novel C-3 methyl, C3–C4 unsaturated analogue.
Here we compare chemical and biological total syntheses to the same metabolites.
This review captures the legacy of natural products in shaping modern infection control and highlights their potential for delivering the next generation of life-saving antibiotics.
This review covers all fungal terpenoid cyclases (TCs), including class I and II TCs as well as emerging UbiA-type TCs, together with their tailoring enzymes, focusing on newly identified TCs and tailoring enzymes from 2015 to August 2023.
The intricate street music box with a series of pins or teeth on a rotating cylinder or disc to play beautiful musical tunes. As exemplified by fungi-derived natural products with structural complexities and diverse bioactivities produced through different biosynthetic pathways.