Recent advances in photorelease complexes for therapeutic applications

Andrew C. Benniston and Lingli Zeng

Dalton Trans., 2022, 51, 4202
DOI: 10.1039/D2DT00254J

Exploiting exo and endo furan-maleimide Diels–Alder linkages for the functionalization of organoruthenium complexes

Hoang-Van Tran, Mohammad Mehdi Haghdoost, Sylvain Poulet, Paul Tcherkawsky and Annie Castonguay

Dalton Trans., 2022, 51, 2214
DOI: 10.1039/D1DT02766B

Ru(ii)/Os(ii)-based carbonic anhydrase inhibitors as photodynamic therapy photosensitizers for the treatment of hypoxic tumours

Youchao Wang, Pierre Mesdom, Kallol Purkait, Bruno Saubaméa, Pierre Burckel, Philippe Arnoux, Céline Frochot, Kevin Cariou, Thibaud Rossel and Gilles Gasser

Chem. Sci., 2023, 14, 11749
DOI: 10.1039/D3SC03932C

Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

Tina P. Andrejević, Ivana Aleksic, Marta Počkaj, Jakob Kljun, Dusan Milivojevic, Nevena Lj. Stevanović, Jasmina Nikodinovic-Runic, Iztok Turel, Miloš I. Djuran and Biljana Đ. Glišić

Dalton Trans., 2021, 50, 2627
DOI: 10.1039/D0DT04061D

Rapid quantification of ruthenium(ii) polypyridyl anti-cancer drugs using a selective ligand dissociation LC-MS/MS method

Stephanie Mehanna, Kikki Bodman-Smith, Costantine F. Daher and Rony S. Khnayzer

Anal. Methods, 2020, 12, 4517
DOI: 10.1039/D0AY01250E

The effect of halogenation of salicylaldehyde on the antiproliferative activities of {Δ/Λ-[Ru(bpy)2(X,Y-sal)]BF4} complexes

Maryam Taghizadeh Shool, Hadi Amiri Rudbari, Tania Gil-Antón, José V. Cuevas-Vicario, Begoña García, Natalia Busto, Nakisa Moini and Olivier Blacque

Dalton Trans., 2022, 51, 7658
DOI: 10.1039/D2DT00401A

Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy

Balaji Babu, Rodah C. Soy, John Mack and Tebello Nyokong

New J. Chem., 2020, 44, 11006
DOI: 10.1039/D0NJ01564D

Characterization and cytotoxicity assessment of nargile smoke using dynamic exposure

Christian Khalil, Joe Braham Chahine, Brenda Chahla, Tamara Hobeika and Rony S. Khnayzer

Inhalation Toxicology, 2019, 31, 343
DOI: 10.1080/08958378.2019.1683104

A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline: A potent chemotherapeutic drug inducing apoptosis in triple negative human breast adenocarcinoma cells

Najwa Mansour, Kikki Bodman-Smith, Rony S. Khnayzer and Costantine F. Daher

Chemico-Biological Interactions, 2021, 336, 109317
DOI: 10.1016/j.cbi.2020.109317

Combination of light and Ru(II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

Luca Conti, Eleonora Macedi, Claudia Giorgi, Barbara Valtancoli and Vieri Fusi

Coordination Chemistry Reviews, 2022, 469, 214656
DOI: 10.1016/j.ccr.2022.214656

Intrinsic 77 K Phosphorescence Characteristics and Computational Modeling of Ru(II)-(Bidentate Cyclometalated-Aromatic Ligand) Chromophores: Their Relatively Low Nonradiative Rate Constants Originating from Low Spin−Orbit Coupling Driven Vibronic Coupling Amplitudes between Emitting and Ground States

Chi-Wei Yin, Li-Ting Zhuo, Jie Ying Chen, Yu-Hui Lin, Yu-Ting Lin, Hsing-Yin Chen, Ming-Kang Tsai and Yuan Jang Chen

Inorg. Chem., 2024, 63, 21981
DOI: 10.1021/acs.inorgchem.4c03390

Low-Temperature Observation of the Excited-State Decay of Ruthenium-(Mono-2,2′:6′,2″-Terpyridine) Ions with Innocent Ligands: DFT Modeling of an 3MLCT–3MC Intersystem Crossing Pathway

Chi-Wei Yin, Ming-Kang Tsai and Yuan Jang Chen

ACS Omega, 2023, 8, 11623
DOI: 10.1021/acsomega.3c01006

Impact of ligand esterification on the cytotoxicity against breast cancer cells of ruthenium(II)/dppb pyridinedicarboxylate complexes

Mariana Santoro de Camargo, Rone Aparecido De Grandis, Ayrton Corrêa Galo, Flávia Aparecida Resende, Pedro Henrique Salgado Marcon, Javier Ellena, João Honorato de Araujo-Neto and Alzir Azevedo Batista

Journal of Inorganic Biochemistry, 2025, 272, 113008
DOI: 10.1016/j.jinorgbio.2025.113008

A Ru(II)-Strained Complex with 2,9-Diphenyl-1,10-phenanthroline Ligand Induces Selective Photoactivatable Chemotherapeutic Activity on Human Alveolar Carcinoma Cells via Apoptosis

Najwa Mansour, Stephanie Mehanna, Kikki Bodman-Smith, Costantine F. Daher and Rony S. Khnayzer

Pharmaceuticals, 2023, 17, 50
DOI: 10.3390/ph17010050

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Johannes Karges, Franz Heinemann, Marta Jakubaszek, Federica Maschietto, Chloé Subecz, Mazzarine Dotou, Robin Vinck, Olivier Blacque, Mickaël Tharaud, Bruno Goud, Emilio Viñuelas Zahı́nos, Bernhard Spingler, Ilaria Ciofini and Gilles Gasser

J. Am. Chem. Soc., 2020, 142, 6578
DOI: 10.1021/jacs.9b13620

The anti-neoplastic potency of epoxy-substituted polyaromatic platinum(II) and platinum(IV) complexes against A549 lung cancer cells

Rouba Al Sayegh, Aleen Khoury, Maria George Elias, Najwa Mansour, Stephanie Mehanna, Amjad Slika, Costantine F. Daher, Janice R. Aldrich-Wright and Robin I. Taleb

European Journal of Medicinal Chemistry, 2025, 294, 117734
DOI: 10.1016/j.ejmech.2025.117734

Synthesis, photophysical properties and photo-induced cytotoxicity of novel tris(diazatriphenylene)ruthenium (II) complex

Srinivas Samala, Woojeong Lim, Dong Kyun You, Kang Mun Lee, Hongil Jo, Kang Min Ok, Jongmin Park and Chang-Hee Lee

Bioorganic Chemistry, 2022, 128, 106044
DOI: 10.1016/j.bioorg.2022.106044

A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway

Maria George Elias, Stephanie Mehanna, Elias Elias, Rony S. Khnayzer and Costantine F. Daher

Chemico-Biological Interactions, 2021, 348, 109644
DOI: 10.1016/j.cbi.2021.109644

Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds

Elizabeth T. Papish and Olaitan E. Oladipupo

Current Opinion in Chemical Biology, 2022, 68, 102143
DOI: 10.1016/j.cbpa.2022.102143

DFT Computational Analysis of the Mechanism of Action of Ru(II) Polypyridyl Complexes as Photoactivated Chemotherapy Agents: From Photoinduced Ligand Solvolysis to DNA Binding

Fortuna Ponte, Daniele Belletto, Roberta Leonetti, Nico Sanna, Stefano Scoditti, Gloria Mazzone and Emilia Sicilia

Inorg. Chem., 2024, 63, 20643
DOI: 10.1021/acs.inorgchem.4c03297

Synthesis and photobiological evaluation of Ru(II) complexes with expanded chelate polypyridyl ligands

Raphael T. Ryan, Austin C. Hachey, Kimberly Stevens, Sean R. Parkin, Richard J. Mitchell, John P. Selegue, David K. Heidary and Edith C. Glazer

Journal of Inorganic Biochemistry, 2023, 238, 112031
DOI: 10.1016/j.jinorgbio.2022.112031

Ruthenium Complexes with Protic Ligands: Influence of the Position of OH Groups and π Expansion on Luminescence and Photocytotoxicity

Olaitan E. Oladipupo, Meredith C. Prescott, Emily R. Blevins, Jessica L. Gray, Colin G. Cameron, Fengrui Qu, Nicholas A. Ward, Abigail L. Pierce, Elizabeth R. Collinson, James Fletcher Hall, Seungjo Park, Yonghyun Kim, Sherri A. McFarland, Igor Fedin and Elizabeth T. Papish

IJMS, 2023, 24, 5980
DOI: 10.3390/ijms24065980

A Novel Branched Copolymer-Containing Anticancer Drug for Targeted Therapy: In Vitro Research

A. Yurchenko, N. Nikitina, V. Sokolova, S. Prylutska, Yu. Kuziv, P. Virych, V. Chumachenko, N. Kutsevol, S. Ponomarenko, Yu. Prylutskyy and M. Epple

BioNanoSci., 2020, 10, 249
DOI: 10.1007/s12668-019-00700-5

Synthesis and Characterization of Ru(II) Polypyridyl Complexes with 2-(4-Methylbenzoate)-1H-imidazo[4,5-f][1,10]phenantroline Ligand, and Their DNA Binding, Photocleavage, Physico-Chemical Properties, and Cytotoxicity

C. Nagamani, P. V. Reddy, M. R. Reddy, K. L. Reddy and S. Satyanarayana

Russ J Gen Chem, 2020, 90, 2456
DOI: 10.1134/S1070363220120385

Light‐responsive and Protic Ruthenium Compounds Bearing Bathophenanthroline and Dihydroxybipyridine Ligands Achieve Nanomolar Toxicity towards Breast Cancer Cells†

Olaitan E. Oladipupo, Spenser R. Brown, Robert W. Lamb, Jessica L. Gray, Colin G. Cameron, Alexa R. DeRegnaucourt, Nicholas A. Ward, James Fletcher Hall, Yifei Xu, Courtney M. Petersen, Fengrui Qu, Ambar B. Shrestha, Matthew K. Thompson, Marco Bonizzoni, Charles Edwin Webster, Sherri A. McFarland, Yonghyun Kim and Elizabeth T. Papish

Photochem & Photobiology, 2022, 98, 102
DOI: 10.1111/php.13508

Drug-free phototherapy of superficial tumors: White light at the end of the tunnel

Stephanie Mehanna, Najwa Mansour, Costantine F. Daher, Maria George Elias, Carole Dagher and Rony S. Khnayzer

Journal of Photochemistry and Photobiology B: Biology, 2021, 224, 112324
DOI: 10.1016/j.jphotobiol.2021.112324

Anticancer Effect of PtIIPHENSS, PtII5MESS, PtII56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer

Maria George Elias, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott and Janice R. Aldrich-Wright

Cancers, 2024, 16, 2544
DOI: 10.3390/cancers16142544

The anti-cancer effect of series of strained photoactivatable Ru(II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells

Christelle Fayad, Hassib Audi, Rony S. Khnayzer and Costantine F. Daher

J Biol Inorg Chem, 2021, 26, 43
DOI: 10.1007/s00775-020-01835-7

A Ru(II) Polypyridyl Complex Bearing Bathocuproine Ligand is a Potent Chemotherapeutic Agent Against Chemically Induced Skin Cancer Model

Maria George Elias, Stephanie Mehanna, Selim Nasser, Costantine F. Daher and Rony S. Khnayzer

Advanced Therapeutics, 2024, 7
DOI: 10.1002/adtp.202400313

Steric hindrance, ligand ejection and associated photocytotoxic properties of ruthenium(II) polypyridyl complexes

Piedad Herrera-Ramírez, Sarah Alina Berger, Dana Josa, David Aguilà, Ana B. Caballero, Pere Fontova, Vanessa Soto-Cerrato, Manuel Martínez and Patrick Gamez

J Biol Inorg Chem, 2023, 28, 403
DOI: 10.1007/s00775-023-01998-z

Enhanced potency of a chloro-substituted polyaromatic platinum(II) complex and its platinum(IV) prodrug against lung cancer

Joy Baz, Aleen Khoury, Maria George Elias, Najwa Mansour, Stephanie Mehanna, Omar Hammoud, Christopher P. Gordon, Robin I. Taleb, Janice R. Aldrich-Wright and Costantine F. Daher

Chemico-Biological Interactions, 2024, 388, 110834
DOI: 10.1016/j.cbi.2023.110834

Thien-2-yl substituted chlorins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy

Balaji Babu, Azole Sindelo, John Mack and Tebello Nyokong

Dyes and Pigments, 2021, 185, 108886
DOI: 10.1016/j.dyepig.2020.108886

Chemotherapeutic Potential of Chlorambucil-Platinum(IV) Prodrugs against Cisplatin-Resistant Colorectal Cancer Cells

Maria George Elias, Angelico D. Aputen, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott and Janice R. Aldrich-Wright

IJMS, 2024, 25, 8252
DOI: 10.3390/ijms25158252

Study of the biological activity of photoactive bipyridyl-Ru(II) complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA)

José Manuel Veiga del Pino, Franco Scalambra, Cristina Bermejo-Casadesús, Anna Massaguer, Federico García-Maroto and Antonio Romerosa

Journal of Inorganic Biochemistry, 2023, 246, 112291
DOI: 10.1016/j.jinorgbio.2023.112291