Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly

Punnida Nonsuwan; Nanami Nishijima; Keita Sakakibara; Tadashi Nakaji-Hirabayashi; Chiaki Yoshikawa

doi:10.1039/D1TB02307A

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Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly†

Punnida Nonsuwan,‡^a Nanami Nishijima,‡^ab Keita Sakakibara,

*^c Tadashi Nakaji-Hirabayashi

*^abd and Chiaki Yoshikawa

*^a

Author affiliations

* Corresponding authors

^a Research Center for Functional Materials, National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0047, Japan
E-mail: yoshikawa.chiaki@nims.go.jp

^b Faculty of Engineering, Academic Assembly, University of Toyama, 3190 Gofuku, Toyama, Toyama 930-8555, Japan

^c Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), 3-11-32 Kagamiyama, Higashi-hiroshima, Hiroshima 739-0046, Japan

^d Graduate School of Innovative Life Science, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan

Abstract

In order to develop new three-dimensional (3D) cell culture systems for articular cartilage regeneration, concentrated poly(styrene sulfonate sodium salt) brush-modified cellulose nanofibers were employed as building blocks for the self-assembly of human mesenchymal stem cells (hMSCs). Unique 3D cellular structures, such as giant spheres and sheets, were formed by controlling hMSC self-assembly.

This article is part of the themed collection: Bioinspired Surfaces Engineering for Biomaterials

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Article information

DOI: https://doi.org/10.1039/D1TB02307A
Article type: Communication
Submitted: 21 Okt. 2021
Accepted: 11 Jan. 2022
First published: 19 Jan. 2022

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J. Mater. Chem. B, 2022,10, 2444-2453

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Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly

P. Nonsuwan, N. Nishijima, K. Sakakibara, T. Nakaji-Hirabayashi and C. Yoshikawa, J. Mater. Chem. B, 2022, 10, 2444 DOI: 10.1039/D1TB02307A

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Journal of Materials Chemistry B

Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly†

Abstract

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Concentrated polymer brush-modified cellulose nanofibers promote chondrogenic differentiation of human mesenchymal stem cells by controlling self-assembly

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