Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

Shuang Chao; Ziyan Shen; Yuxin Pei; Yinghua Lv; Xiaolin Chen; Jiaming Ren; Ke Yang; Zhichao Pei

doi:10.1039/D1CC02959B

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Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness†

Shuang Chao,‡^a Ziyan Shen,‡^a Yuxin Pei,

^a Yinghua Lv,^a Xiaolin Chen,^a Jiaming Ren,^a Ke Yang^a and Zhichao Pei

*^a

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* Corresponding authors

^a Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, P. R. China
E-mail: peizc@nwafu.edu.cn
Fax: +86-29-8709-2769
Tel: +86-29-8709-2769

Abstract

A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host–guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.

This article is part of the themed collections: Host-Guest Chemistry and Chemical Communications HOT articles

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DOI: https://doi.org/10.1039/D1CC02959B
Article type: Communication
Submitted: 04 Jun. 2021
Accepted: 29 Jun. 2021
First published: 30 Jun. 2021

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Chem. Commun., 2021,57, 7625-7628

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Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

S. Chao, Z. Shen, Y. Pei, Y. Lv, X. Chen, J. Ren, K. Yang and Z. Pei, Chem. Commun., 2021, 57, 7625 DOI: 10.1039/D1CC02959B

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Chemical Communications

Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness†

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Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness

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