Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?†
Yuko P. Y.
Lam, 
a
Cookson K. C.
Chiu,
a
Christopher A.
Wootton,
a
Ian
Hands-Portman,
b
Meng
Li,
a
Mark P.
Barrow
a
and
Peter B.
O'Connor
*a
a
Cookson K. C.
Chiu,
a
Christopher A.
Wootton,
a
Ian
Hands-Portman,
b
Meng
Li,
a
Mark P.
Barrow
a
and
Peter B.
O'Connor
*a
Abstract
Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.
- This article is part of the themed collection: Chemical Communications HOT Articles
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