Copper mediated C(sp2)–H amination and hydroxylation of phosphinamides

Shang-Zheng Sun; Ming Shang; Hui Xu; Tai-Jin Cheng; Ming-Hong Li; Hui-Xiong Dai

doi:10.1039/C9CC08879B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Copper mediated C(sp²)–H amination and hydroxylation of phosphinamides†

Shang-Zheng Sun,

‡^a Ming Shang,‡^b Hui Xu,^c Tai-Jin Cheng,^c Ming-Hong Li^c and Hui-Xiong Dai

*^c

Author affiliations

* Corresponding authors

^a Department of Chemistry, Innovative Drug Research Center, Shanghai University, 99 Shangda Road, Shanghai, China

^b Department of Chemistry, The Scripps Research Institute, 10550N. Torrey Pines Road, La Jolla, California 92037, USA

^c Chinese Academy of Sciences Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China
E-mail: hxdai@simm.ac.cn

Abstract

Copper mediated C(sp²)–H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group. This method is distinguished by its wide substrate scope and excellent functional group tolerance, thus allowing for the rapid preparation of organophosphorus compounds in organic synthesis.

This article is part of the themed collection: Organic Synthesis

Download options Please wait...

Supplementary files

Supplementary information PDF (3979K)

Article information

DOI: https://doi.org/10.1039/C9CC08879B
Article type: Communication
Submitted: 13 Nov. 2019
Accepted: 20 Des. 2019
First published: 21 Des. 2019

Download Citation

Chem. Commun., 2020,56, 1444-1447

Permissions

Request permissions

Copper mediated C(sp²)–H amination and hydroxylation of phosphinamides

S. Sun, M. Shang, H. Xu, T. Cheng, M. Li and H. Dai, Chem. Commun., 2020, 56, 1444 DOI: 10.1039/C9CC08879B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications