Issue 16, 2019

True one cell chemical analysis: a review

Abstract

The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.

Graphical abstract: True one cell chemical analysis: a review

Article information

Article type
Tutorial Review
Submitted
27 Mrt. 2019
Accepted
20 Mei 2019
First published
23 Mei 2019

Analyst, 2019,144, 4733-4749

True one cell chemical analysis: a review

I. W. De Silva, A. R. Kretsch, H. Lewis, M. Bailey and G. F. Verbeck, Analyst, 2019, 144, 4733 DOI: 10.1039/C9AN00558G

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