Issue 48, 2008
From the journal:

Chemical Communications

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery†

Ahn Na Koo,a   Hong Jae Lee,a   Sung Eun Kim,a   Jeong Ho Chang,a   Chiyoung Park,b   Chulhee Kim,b   Jae Hyung Parkc  and  Sang Cheon Lee*a  

* Corresponding authors

a Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul, Korea
E-mail: sclee@kicet.re.kr
Fax: +82 2 3282 7811
Tel: +82 2 3282 2469

b Department of Polymer Science andEngineering, Hyperstructured Organic Materials Research Center, Inha University, Incheon, Korea

c Departments of Advanced Polymer and Nanopharmaceutical Sciences, Kyung Hee University, Gyeonggi-do, Korea

Abstract

We report biocompatible, cell-permeable core–shell–corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Graphical abstract: Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B815918A
Article type
Communication
Submitted
11 Sep. 2008
Accepted
28 Okt. 2008
First published
12 Nov. 2008

Chem. Commun., 2008, 6570-6572

Permissions

Request permissions

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

A. N. Koo, H. J. Lee, S. E. Kim, J. H. Chang, C. Park, C. Kim, J. H. Park and S. C. Lee, Chem. Commun., 2008, 6570 DOI: 10.1039/B815918A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements