Issue 4, 2024

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Abstract

Ginsenosides are a class of natural products with hormone-like activity of triterpenoid saponins and have a variety of pharmacological activities such as anti-aging, immune regulation and cognitive improvement. With the great research interest in alternative medicine and natural products, they are gradually becoming research hotspots. Ginsenosides have a four-ring rigid steroid backbone similar to steroid hormones, and a series of experimental studies have shown that they can exhibit hormone-like activity by binding to nuclear receptors or affecting hormone levels, thereby affecting a wide range of inflammatory conditions, cancers, and menopause-related diseases. This review summarizes the mechanisms and potential health effects of ginsenosides exhibiting estrogen-like, glucocorticoid-like and androgen-like activities, providing an important reference for the exploration of safe phytohormone replacement therapy.

Graphical abstract: Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Article information

Article type
Review Article
Submitted
11 Des. 2023
Accepted
20 Jan. 2024
First published
22 Jan. 2024

Food Funct., 2024,15, 1825-1839

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

J. Li, J. Zhao, X. Wang, Z. Lin, H. Lin and Z. Lin, Food Funct., 2024, 15, 1825 DOI: 10.1039/D3FO05484E

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