Issue 73, 2018
From the journal:

Chemical Communications

Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite†

Jia Hao Pang,a   Atsushi Kagaa  and  Shunsuke Chiba ORCID logo *a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: shunsuke@ntu.edu.sg

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

Graphical abstract: Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

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Article information

DOI
https://doi.org/10.1039/C8CC05979A
Article type
Communication
Submitted
24 Jul. 2018
Accepted
15 Aug. 2018
First published
16 Aug. 2018

Chem. Commun., 2018,54, 10324-10327

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Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

J. H. Pang, A. Kaga and S. Chiba, Chem. Commun., 2018, 54, 10324 DOI: 10.1039/C8CC05979A

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