Ketan D. Patel, Monica R. MacDonald, Syed Fardin Ahmed, Jitendra Singh and Andrew M. Gulick
Nat. Prod. Rep., 2023,40, 1550-1582
From themed collection:
Looking Inside Biosynthetic Machines
Abstract
Nonribosomal peptide synthetases use a modular architecture to catalyze production of peptide natural products. Structural studies provide insights into the multidomain organization as well as the structural basis of catalytic domain activity.
Jialiang Wang, Zixin Deng, Jingdan Liang and Zhijun Wang
Nat. Prod. Rep., 2023,40, 1498-1520
From themed collection:
Looking Inside Biosynthetic Machines
Abstract
This article provides a comprehensive overview of the structural enzymology of type I iPKSs, focusing on the individual domain structures, catalytic mechanisms and the representative programming activities that each domain contributes.
Itai Sharon, Donald Hilvert and T. Martin Schmeing
Nat. Prod. Rep., 2023,40, 1479-1497
From themed collection:
Looking Inside Biosynthetic Machines
Abstract
Cyanophycin is a widespread natural biopolymer with promising green chemistry applications that is made by an elegant, multifunctional biosynthetic machine.
Yu-Hsuan Lee, Daan Ren, Byungsun Jeon and Hung-wen Liu
Nat. Prod. Rep., 2023,40, 1521-1549
From themed collection:
Looking Inside Biosynthetic Machines
Abstract
This review summarizes the chemistry of S-adenosylmethionine dependent enzymes that goes beyond methylation.
Saket R. Bagde and Chu-Young Kim
Nat. Prod. Rep., 2024, Advance Article
From themed collection:
Looking Inside Biosynthetic Machines
Abstract
Structures of intact polyketide synthase modules reveal conformational rearrangements and suggest asynchronous use of reaction chambers.
Manuel Montalbán-López, Thomas A. Scott, Sangeetha Ramesh, Imran R. Rahman, Auke J. van Heel, Jakob H. Viel, Vahe Bandarian, Elke Dittmann, Olga Genilloud, Yuki Goto, María José Grande Burgos, Colin Hill, Seokhee Kim, Jesko Koehnke, John A. Latham, A. James Link, Beatriz Martínez, Satish K. Nair, Yvain Nicolet, Sylvie Rebuffat, Hans-Georg Sahl, Dipti Sareen, Eric W. Schmidt, Lutz Schmitt, Konstantin Severinov, Roderich D. Süssmuth, Andrew W. Truman, Huan Wang, Jing-Ke Weng, Gilles P. van Wezel, Qi Zhang, Jin Zhong, Jörn Piel, Douglas A. Mitchell, Oscar P. Kuipers and Wilfred A. van der Donk
Nat. Prod. Rep., 2021,38, 130-239
Abstract
This review provides a comprehensive update of the advances in discovery, biosynthesis, and engineering of ribosomally-synthesized and post-translationally modified peptides (RiPPs).
Suze Ma, Dhanaraju Mandalapu, Shu Wang and Qi Zhang
Nat. Prod. Rep., 2022,39, 926-945
Abstract
This review discusses the diverse enzymatic pathways in the biosynthesis of cyclopropane, a unique structural motif with important biochemical properties.
Linlin Pang, Daichen Yao, Fenghui Gao, Xiaoying Bian, Youming Zhang and Guannan Zhong
Org. Biomol. Chem., 2023,21, 7242-7254
Abstract
This review aims to provide an overview of the biosyntheses of the striking azetidine-containing natural products, with an emphasis on the biosynthetic mechanisms of naturally occurring azetidines.
Dmitrii Y. Travin, Konstantin Severinov and Svetlana Dubiley
RSC Chem. Biol., 2021,2, 468-485
From themed collection:
Small molecules for chemical biology
Abstract
The structures, biosynthesis, and modes of action of albomycin, microcin C and agrocin 84, antibiotics targeting aminoacyl-tRNA synthetases, are reviewed. Using bioinformatics several new putative aminoacyl-tRNA synthetase inhibitors are predicted.
Anwei Hou and Jeroen S. Dickschat
Nat. Prod. Rep., 2023,40, 470-499
Abstract
This review summarises the recent studies on the biosynthesis of polyketides, non-ribosomal peptides and their hybrids using isotopic labelling experiments.