From the journal RSC Chemical Biology Peer review history
Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: overlapping biology with cancer
Round 1
Manuscript submitted on 02 Cig 2021![](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/icon-letter.png)
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06-Jun-2021
Dear Dr Kalyanaraman:
Manuscript ID: CB-REV-03-2021-000042
TITLE: Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: Overlapping biology with cancer and repurposing drugs
Thank you for your submission to RSC Chemical Biology, published by the Royal Society of Chemistry. I sent your manuscript to reviewers and I have now received their reports which are copied below.
After careful evaluation of your manuscript and the reviewers’ reports, I will be pleased to accept your manuscript for publication after revisions.
Please revise your manuscript to fully address the reviewers’ comments. When you submit your revised manuscript please include a point by point response to the reviewers’ comments and highlight the changes you have made. Full details of the files you need to submit are listed at the end of this email.
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I look forward to receiving your revised manuscript.
Yours sincerely,
Professor Zaneta Nikolovska-Coleska
Associate Editor, RSC Chemical Biology
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Reviewer 1
It would be interesting to include the role of glucose metabolism in Redox balance via glutathione regulation and how this reducing agent levels determine pathophysiology of Cancer, Covid-19 and inflammation.
Reviewer 2
Dear author,
Thank you for the tremendous and thoughtful piece of work you've put together! Considering the real life application in our current world, this piece has come out in a very timely manner.
There's a couple minor revisions I would recommend to better allow the audience to digest all of the valuable information you've provided. Your thought process is entirely logical, but here are some suggestions to help add clarity. Since immunology is still a newer field, it would be great if you could provide a glossary as an appendix. Additionally, it would be wonderful if you could also include a table with all of the acronyms as a point of reference. These two things would allow the reader to continue engaging with your points, as it's pretty dense and filled with lots of information.
Thank you!
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Response to Reviewers
I think the reviewers for the positive feedback about the manuscript. Responses to the individual comments are included in below.
Referee: 1
Comments to the Author
It would be interesting to include the role of glucose metabolism in Redox balance via glutathione regulation and how this reducing agent levels determine pathophysiology of Cancer, Covid-19 and inflammation.
Author response: We have added a section on the effect of 2-DG (an inhibitor of aerobic glycolytic mechanism) and the emerging literature describing the mechanism. Clearly, glutathione regulation plays an important role in understanding the effect of 2-DG. It is particularly interesting and significant, as 2-DG has received an emergency use authorization in moderately and severely ill COVID-19 patients in India. We thank the reviewer for encouraging us to include a section on glucose metabolism.
Referee: 2
Comments to the Author
Dear author,
Thank you for the tremendous and thoughtful piece of work you've put together! Considering the real life application in our current world, this piece has come out in a very timely manner.
There's a couple minor revisions I would recommend to better allow the audience to digest all of the valuable information you've provided. Your thought process is entirely logical, but here are some suggestions to help add clarity. Since immunology is still a newer field, it would be great if you could provide a glossary as an appendix. Additionally, it would be wonderful if you could also include a table with all of the acronyms as a point of reference. These two things would allow the reader to continue engaging with your points, as it's pretty dense and filled with lots of information.
Thank you!
Author response: We are humbled by the kind words and thankful to the reviewer. In response to the reviewer’s suggestion, we have included a table with the acronyms used in the manuscript.
Round 2
Revised manuscript submitted on 08 Qas 2021![](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/icon-letter.png)
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30-Jun-2021
Dear Dr Kalyanaraman:
Manuscript ID: CB-REV-03-2021-000042.R1
TITLE: Reactive oxygen species, proinflammatory and immunosuppressive mediators induced in COVID-19: Overlapping biology with cancer
Thank you for submitting your revised manuscript to RSC Chemical Biology. After considering the changes you have made, I am pleased to accept your manuscript for publication in its current form. I have copied any final comments from the reviewer(s) below.
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Thank you for publishing with RSC Chemical Biology, a journal published by the Royal Society of Chemistry – connecting the world of science to advance chemical knowledge for a better future.
With best wishes,
Professor Zaneta Nikolovska-Coleska
Associate Editor, RSC Chemical Biology
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Reviewer 1
Fidelis Toloyi Ndombera
Transparent peer review
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