Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies

Hafiza Zara Tariq, Aamer Saeed, Saeed Ullah, Noor Fatima, Sobia Ahsan Halim, Ajmal Khan, Hesham R. El-Seedi, Muhammad Zaman Ashraf, Muhammad Latif and Ahmed Al-Harrasi

RSC Adv., 2023, 13, 26229
DOI: 10.1039/D3RA03953F

Quinazolinone-1,2,3-triazole-acetamide conjugates as potent α-glucosidase inhibitors: synthesis, enzyme inhibition, kinetic analysis, and molecular docking study

Sara Moghadam Farid, Aida Iraji, Somayeh Mojtabavi, Mehrnaz Ghasemi, Mohammad Ali Faramarzi, Mohammad Mahdavi, Maliheh Barazandeh Tehrani, Tahmineh Akbarzadeh and Mina Saeedi

RSC Med. Chem., 2023, 14, 520
DOI: 10.1039/D2MD00297C

Synthesis, structural insights and bio-evaluation of N-phenoxyethylisatin hydrazones as potent α-glucosidase inhibitors

Saba Mehreen, Muhammad Imran Ali, Sidra tul Muntha, Mehwash Zia, Aman Ullah, Saeed Ullah, Ajmal Khan, Javid Hussain, Muhammad U. Anwar, Ahmed Al-Harrasi and Muhammad Moazzam Naseer

RSC Adv., 2025, 15, 14717
DOI: 10.1039/D5RA00770D

Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

Alia Mushtaq, Rabbia Asif, Waqar Ahmed Humayun and Muhammad Moazzam Naseer

RSC Adv., 2024, 14, 14051
DOI: 10.1039/D4RA01937G

Facile synthesis, Spectral investigation, in vitro and in silico studies of Thiophenecarboxamide-α,β-unsaturated ketone hybrids

Manikkam Bharathi, S. Shreedevi and Rajendran Sribalan

Journal of Molecular Structure, 2024, 1308, 138060
DOI: 10.1016/j.molstruc.2024.138060

Pyrano[2,3-b]chromone derivatives as novel dual inhibitors of α-glucosidase and α-amylase: Design, synthesis, biological evaluation, and in silico studies

Elnaz Farzaneh, Mohammad Mohammadi, Pooya Raymand, Milad Noori, Sahand Golestani, Sara Ranjbar, Younes Ghasemi, Maryam Mohammadi-Khanaposhtani, Mehdi Asadi, Ensieh Nasli Esfahani, Hossein Rastegar, Bagher Larijani, Mohammad Mahdavi and Parham Taslimi

Bioorganic Chemistry, 2024, 145, 107207
DOI: 10.1016/j.bioorg.2024.107207

Probing the biological activity of isatin derivatives against human lung cancer A549 cells: Cytotoxicity, CT-DNA/BSA binding, DFT/TD-DFT, topology, ADME-Tox, docking and dynamic simulations

Mehran Feizi-Dehnayebi, Ghodsi Mohammadi Ziarani, T.N. Lohith, Somayyeh Ghareghomi, Zahra Panahande, Majid Farsadrooh and Maryam Majidinia

Journal of Molecular Liquids, 2025, 428, 127475
DOI: 10.1016/j.molliq.2025.127475

Synthesis and bioactivities evaluation of quinazolin-4(3H)-one derivatives as α-glucosidase inhibitors

Mahshid Moheb, Aida Iraji, Navid Dastyafteh, Minoo Khalili Ghomi, Milad Noori, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fatemeh Rasekh, Bagher Larijani, Kamiar Zomorodian, Seyed Esmaeil Sadat-Ebrahimi and Mohammad Mahdavi

BMC Chemistry, 2022, 16
DOI: 10.1186/s13065-022-00885-z

The Isatin Scaffold: Exceptional Potential for the Design of Potent Bioactive Molecules

Habiba Nazir and Muhammad Moazzam Naseer

Synlett, 2025
DOI: 10.1055/a-2595-6787

Synthesis of new phenoxymethylcoumarin clubbed 4-arylthiazolylhydrazines as α-glucosidase inhibitors and their kinetics and molecular docking studies

Qurat ul Ain, Aamer Saeed, Ajmal Khan, Atteeque Ahmed, Saeed Ullah, Sobia Ahsan Halim, Madiha Irfan, Arfa Tehzeeb, Hesham R. El-Seedi, Abdullatif Bin Muhsinah and Ahmed Al-Harrasi

Bioorganic Chemistry, 2023, 131, 106302
DOI: 10.1016/j.bioorg.2022.106302

In-vitro, in-silico studies on the proposed penasulfate A and its derivatives as dual inhibitors of α-glucosidases and human cancer cells

Changxuan Deng, Fei Ding, Chuanfang Zhao, Nan Zhang, Hanlin Lin, Wangting Lu, Yanhua Yu, Xianran He, Yongmin Zhang and Yangguang Gao

Journal of Molecular Structure, 2024, 1295, 136521
DOI: 10.1016/j.molstruc.2023.136521

Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes

Syed Parween Ali, Farheen Mansoor, Shaymaa Fadhel Abbas Albaayit, Farman Ali, Ayed A. Dera, Muhammad Shahbaz, Jawad Ullah, Hailah M. Almohaimeed, Reem M. Gahtani, Ahmed M. Abdulfattah, Fahad M. Alshabrmi, Sarfaraz Alam and Saeed Ullah

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-82765-1

Antidiabetic potential of Moroccan medicinal plant extracts: a virtual screening using in silico approaches

Bouchra Rossafi, Amal Bouribab, Oussama Abchir, Meriem Khedraoui, Mhammed El Kouali and Samir Chtita

Results in Chemistry, 2025, 16, 102365
DOI: 10.1016/j.rechem.2025.102365

Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity

Mohammad Kazempour-Dizaji, Somayeh Mojtabavi, Arash Sadri, Araz Ghanbarpour, Mohammad Ali Faramarzi and Latifeh Navidpour

Bioorganic Chemistry, 2023, 139, 106709
DOI: 10.1016/j.bioorg.2023.106709

Iodine uptake enhanced electrical conductivity by a metal-organic framework bearing nanotube array of π-stacked columns

Ting Chen, Shun Li, Zuo-Bei Wang, Zhi-Yan Wu, Min Huang, Wei Wang, Zhu Zhuo and You-Gui Huang

Journal of Molecular Structure, 2023, 1289, 135858
DOI: 10.1016/j.molstruc.2023.135858

Apigenin analogs as α-glucosidase inhibitors: Molecular docking, biochemical, enzyme kinetic, and an in vivo mouse model study

Honghui Liu, Yanxu Wei, Yan Wang, Qiu Zhao, Lan Liu, Hong Ding and Yuntian Hong

Bioorganic Chemistry, 2024, 153, 107956
DOI: 10.1016/j.bioorg.2024.107956

Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches

Anam Rubbab Pasha, Ajmal Khan, Saeed Ullah, Sobia Ahsan Halim, Javid Hussain, Muhammad Khalid, Muhammad Moazzam Naseer, Attalla F. El-kott, Sally Negm, Ahmed Al-Harrasi and Zahid Shafiq

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-28828-1

Investigations on 3D-structure, properties and antibacterial activity of two new curcumin derivatives

D. Reuben Jonathan, Era. DravidaThendral, M. Krishna Priya, D. Angeline Shirmila, A Anish Fathima, R Yuvashri and G. Usha

Journal of Molecular Structure, 2023, 1292, 136063
DOI: 10.1016/j.molstruc.2023.136063

Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors

Rabia Basri, Saeed Ullah, Sobia Ahsan Halim, Rima D. Alharthy, Umair Rauf, Ajmal Khan, Javid Hussain, Ahmed Al‐Ghafri, Ahmed Al‐Harrasi and Zahid Shafiq

Drug Development Research, 2023, 84, 962
DOI: 10.1002/ddr.22065

Synthesis, in vitro α-glucosidase and α-amylase activities and molecular docking study of oxadiazole-sulphonamide hybrid analogues

Hayat Ullah, Muhammad Waseem Aslam, Fazal Rahim, Amjad Hussain and Muhammad Perviaz

Chemical Data Collections, 2023, 45, 101031
DOI: 10.1016/j.cdc.2023.101031

Synthesis of 1,2,3‐triazole‐1,3,4‐thiadiazole hybrids as novel α‐glucosidase inhibitors by in situ azidation/click assembly

Hariom Kumar, Manoj Dhameja, Sirisha Kurella, Adepally Uma and Preeti Gupta

Archiv der Pharmazie, 2023, 356
DOI: 10.1002/ardp.202300145

Methyl 2-[(Z)-5-methyl-2-oxoindolin-3-ylidene]hydrazinecarbodithioate

Mohd Abdul Fatah Abdul Manan, David B. Cordes and Aidan P. McKay

IUCrData, 2024, 9
DOI: 10.1107/S2414314624009672

Synthesis, X-ray crystallography, COSMO-RS, and molecular electronic property investigation of a novel N-alkyl-substituted 5-chloroisatin derivative

Abderrazzak El Moutaouakil Ala Allah, Mouslim Messali, Abdelaziz Sabik, Benson M. Kariuki, Han-seung Lee, Abdullah Yahya Abdullah Alzahrani, Hassane Lgaz and Youssef Ramli

Journal of Molecular Structure, 2025, 1344, 142995
DOI: 10.1016/j.molstruc.2025.142995

Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges

Alia Mushtaq, Uzma Azam, Saba Mehreen and Muhammad Moazzam Naseer

European Journal of Medicinal Chemistry, 2023, 249, 115119
DOI: 10.1016/j.ejmech.2023.115119

Design, synthesis, characterization and biological screening of novel thiosemicarbazones and their derivatives with potent antibacterial and antidiabetic activities

Waseem Shoukat, Mazhar Hussain, Awais Ali, Nusrat Shafiq, Adeel H. Chughtai, Bushra Shakoor, Aniqa Moveed, Muhammad Nadeem Shoukat, Marija Milošević and Mohamed Mohany

Journal of Molecular Structure, 2025, 1320, 139614
DOI: 10.1016/j.molstruc.2024.139614

Development of coumarin tagged 1,2,3-triazole derivatives targeting α-glucosidase inhibition: Synthetic modification, biological evaluation, kinetic and in silico studies

Marzieh Aghaei Khouzani, Mehdi Mogharabi, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Homa Azizian, Mohammad Mahdavi and Seyedeh Mahdieh Hashemi

Journal of Molecular Structure, 2023, 1282, 135194
DOI: 10.1016/j.molstruc.2023.135194

Synthesis and bio-evaluation of newer dihydropyridines and tetrahydropyridines based glycomimetic azasugars

Nidhi Deswal, Priya Takkar, Lajpreet Kaur, Himanshu Ojha and Rakesh Kumar

Bioorganic Chemistry, 2024, 145, 107224
DOI: 10.1016/j.bioorg.2024.107224

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes

Faiz Talab, Saeed Ullah, Aftab Alam, Sobia Ahsan Halim, Najeeb Ur Rehman, Zainab, Mumtaz Ali, Abdul Latif, Ajmal Khan, Ahmed Al-Harrasi and Manzoor Ahmad

ACS Omega, 2023, 8, 6234
DOI: 10.1021/acsomega.2c05390

Molecular duplexes featuring NH···N, CH···O and CH···π interactions in solid-state self-assembly of triazine-based compounds

Shazia Asghar, Shahid Hameed, Muhammad Nawaz Tahir and Muhammad Moazzam Naseer

R. Soc. open sci., 2022, 9
DOI: 10.1098/rsos.220603

4-Phenylthiazol-1,2,3-triazole derivatives as new potential α-glucosidase and α-amylase inhibitors

Mehdi Ghanbarlou, Somaye Karimian, Fatemeh Doraghi, Armin Dadgar, İlbilge Merve Şenol, Bagher Larijani, Maryam Mohammadi-Khanaposhtani, Aydın Aktaş, Nastaran Sadeghian, Parham Taslimi, Mina Ebrahimi-Rad, Mohammad Mahdavi and İlhami Gülçin

Journal of Molecular Structure, 2025, 1334, 141919
DOI: 10.1016/j.molstruc.2025.141919

Synthesis and characterization of some novel benzoyl thioureas as potent α-glucosidase inhibitors: In vitro and in silico

Muhammad Azeem Shakil, Saeed Ullah, Sobia Ahsan Halim, Khalid Mahmood, Muhammad Hanif, Muhammad Khalid, Ajaz Hussain, Faizullah Khan, Ataf Ali Altaf, Muhammad Rashid, Ajmal Khan, Muhammad U. Anwar and Ahmed Al-Harrasi

Journal of Molecular Structure, 2024, 1308, 138133
DOI: 10.1016/j.molstruc.2024.138133

Synthesis, Characterization, and DFT Study of Mono- and Di-Arylated Pyridine Derivatives

Ilham Khan, Muhammad Adeel, Tansir Ahamad, Muhammad Sohail Khan, Gregor Schnakenburg, Sarfraz Ahmed, Suvash Chandra Ojha and Muhammad Adnan Asghar

Polycyclic Aromatic Compounds, 2024, 44, 4639
DOI: 10.1080/10406638.2023.2254907