Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Emel Mataracı-Kara, Berna Özbek-Çelik, Masami Otsuka, Mikako Fujita, Mohamed O. Radwan and Amaç Fatih TuYuN

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Photocatalyst-free visible-light-induced cross-dehydrogenative sulfenylation of aminocoumarins and amino-1,4-naphthoquinones

Papiya Sikdar, Tathagata Choudhuri, Sourav Das, Suvam Paul and Avik Kumar Bagdi

New J. Chem., 2026
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Chlorinated plastoquinone analogs that inhibit Staphylococcus epidermidis and Candida albicans growth

Emel Mataracı Kara, Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Berna Ozbek Celik and Amaç Fatih Tuyun

Folia Microbiol, 2020, 65, 785
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Synthesis, electrochemical and anti-microbial study of 2,5-diamino benzoquinones

A. Asha and S. Suma

Journal of the Indian Chemical Society, 2022, 99, 100316
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Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans

Fernanda Petzold Pauli, Cyntia Silva Freitas, Patricia Ribeiro Pereira, Alviclér Magalhães, Fernando de Carvalho da Silva, Vania M. F. Paschoalin and Vitor Francisco Ferreira

Polymers, 2023, 15, 1430
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Synthesis and Structural Analysis of Some New Sulfanyl Amino 1,4-Naphthoquinone Derivatives

Hatice YILDIRIM

Journal of the Turkish Chemical Society, Section A: Chemistry, 2017, 149
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Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, Masami Otsuka, Mikako Fujita, Amaç Fatih Tuyun and Halil I. Ciftci

Bioorganic Chemistry, 2019, 92, 103255
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Synthesis of New 2-Amino-3-(2-Oxothiazol-Methyl)-Substituted-1,4-Naphthoquinone Derivatives Based on Silica Nanoparticles as a Reusable Heterogeneous Catalyst

Hassan Vasheghani Farahani, Mohammad Bayat and Shima Nasri

Silicon, 2020, 12, 41
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Arylthio analogs of 5,8-quinolinedione: Synthesis, characterization, antibacterial, and antifungal evaluations

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Phosphorus, Sulfur, and Silicon and the Related Elements, 2020, 195, 516
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In Vitro and In Vivo Biological Evaluation of Novel 1,4‐Naphthoquinone Derivatives as Potential Anticancer Agents

Palanisamy Ravichandiran, Aleksandra Martyna, Elżbieta Kochanowicz, Nikhil Maroli, Konrad Kubiński, Maciej Masłyk, Anna Boguszewska‐Czubara and Thiyagarajan Ramesh

ChemMedChem, 2024, 19
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Synthesis, characterization, and biological evaluation of a set of new alkylthio substituted plastoquinones containing ester group

Hatice Yıldırım

Journal of Molecular Structure, 2020, 1203, 127433
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Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth

Emel Mataracı-Kara, Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Merve Ataman, Berna Ozbek-Celik and Amaç Fatih Tuyun

Med Chem Res, 2021, 30, 1728
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The Antifungal Activity of Naphthoquinones: An Integrative Review

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Evaluation of Biological Activities of Quinone-4-oxoquinoline Derivatives against Pathogens of Clinical Importance

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A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity

Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, Masami Otsuka, Mikako Fujita, Halil I. Ciftci and Amaç Fatih Tuyun

Chem Biol Drug Des, 2020, 95, 343
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Crystal Structures of 2-Chloro-3-((3-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione and 2-Chloro-3-((4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione

Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Musa Sahin and Amaç Fatih Tuyun

Crystallogr. Rep., 2019, 64, 1030
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Direct Functionalization of para‐Quinones: A Historical Review and New Perspectives

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Eur J Org Chem, 2024, 27
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Design, fabrication and optical characterizations of pyrimidine fused quinolone carboxylate moiety for photodiode applications

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Optik, 2020, 216, 164882
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Exploration of brominated Plastoquinone analogs: Discovery and structure-activity relationships of small antimicrobial lead molecules

Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Emel Mataracı-Kara, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih Tuyun

Bioorganic Chemistry, 2021, 116, 105316
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Description of Some Methodologies for the Synthesis of 1,4-Naphthoquinone Derivatives and Examples of their Biological Activity: A Review

Silvia E. Loredo-Carrillo, Elisa Leyva, Lluvia Itzel López-López, Gabriela Navarro-Tovar, Denisse de Loera and Sarai Vega-Rodríguez

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Mono- and bis-1,4-naphthoquinone thioethers: synthesis, electrochemical properties, antioxidant and antibacterial activity

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Synthesis, characterization, molecular docking and anticancer studies of fluoroaniline derivatives of hydroxybenzoquinone and hydroxynaphthoquinone

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Journal of Biomolecular Structure and Dynamics, 2022, 40, 3917
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Active Quinolinequinones against Methicillin‐Resistant Staphylococcus spp

Emel Mataracı‐Kara, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım and Amaç Fatih TuYuN

Chemistry & Biodiversity, 2022, 19
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Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Betul Karademir Yilmaz, Deepak Shilkar, Raghusrinivasan Jayaprakash Venkatesan, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Pharmaceuticals, 2022, 15, 777
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Pseudo‐Multicomponent Reactions of Lawsone: Synthetic Strategies of Bis‐Lawsone

Swadhin Swaraj Acharya, Dibyaranjan Samantaray, Chipuru Sibakrishna and Bibhuti Bhusan Parida

ChemistrySelect, 2025, 10
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Design, Synthesis, and Antibacterial Activities of Multi‐Functional C2‐Functionalized 1,4‐Naphthoquinonyl Organoseleniums

Raushan Kumar Jha, Chhavi, Svastik Jaiswal, Devendra Parganiha, Vishal Choudhary, Deepanshi Saxena, Rahul Maitra, Swechcha Singh, Sidharth Chopra and Sangit Kumar

Chemistry An Asian Journal, 2025, 20
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Systematic Review on Cytotoxic and Anticancer Potential of N-Substituted Isatins as Novel Class of Compounds Useful in Multidrug-Resistant Cancer Therapy: In Silico and In Vitro Analysis

Alpana K. Gupta, Sonam Tulsyan, Mausumi Bharadwaj and Ravi Mehrotra

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Discovery and structure–activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells

Halil I. Ciftci, Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, Masami Otsuka, Mikako Fujita and Amaç F. Tuyun

Archiv der Pharmazie, 2019, 352
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Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, In Vitro Evaluation, and Putative Mode of Action

Hatice Yıldırım, Nilüfer Bayrak, Mahmut Yıldız, Emel Mataracı-Kara, Serol Korkmaz, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih TuYuN

ACS Omega, 2022, 7, 41915
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Investigation of the antimicrobial and anticancer activity of aminonaphthoquinones

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Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy

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Catalytic application of a nano-molten salt catalyst in the synthesis of biological naphthoquinone-based compounds

Meysam Yarie, Mohammad Ali Zolfigol, Saeed Babaee, Saeed Baghery, Diego A. Alonso and Abbas Khoshnood

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Some new NH-, NH,S-, S,S- and NH,NH- substituted 1,4-naphtho(benzo)quinones

Aysecik Kacmaz

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Synthesis, electrochemistry, in-situ spectroelectrochemistry and molecular structures of 1,4-naphthoquinone derivatives

Nahide Gulsah Deniz, Cigdem Sayil, Duygu Akyüz and Atif Koca

Journal of Molecular Structure, 2021, 1224, 129145
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Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells

Ayse Tarbin Jannuzzi, Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Chemico-Biological Interactions, 2021, 349, 109673
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Blue Light Irradiated Metal-, Oxidant-, and Base-Free Cross-Dehydrogenative Coupling of C(sp2)–H and N–H Bonds: Amination of Naphthoquinones with Amines

Raushan Kumar Jha, Monojit Batabyal and Sangit Kumar

J. Org. Chem., 2023, 88, 7401
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Discovery and s tructure–activity relationships of the quinolinequinones: Promising antimicrobial agents and mode of action evaluation

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Drug Dev Res, 2021
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Synthesis of Some Mono-, Bis- NH-substituted-1,4-Benzoquinones

Aysecik KACMAZ

Journal of the Turkish Chemical Society Section A: Chemistry, 2018, 5, 963
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The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Gabriela Navarro-Tovar, Sarai Vega-Rodríguez, Elisa Leyva, Silvia Loredo-Carrillo, Denisse de Loera and Lluvia Itzel López-López

Pharmaceuticals, 2023, 16, 496
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Synthesis and Antimicrobial Evaluation of 1,4‐Naphthoquinone Derivatives as Potential Antibacterial Agents

Palanisamy Ravichandiran, Maciej Masłyk, Sunirmal Sheet, Monika Janeczko, Dhanraj Premnath, Ae Rhan Kim, Byung‐Hyun Park, Myung‐Kwan Han and Dong Jin Yoo

ChemistryOpen, 2019, 8, 589
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Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation

Amaç F. Tuyun, Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Emel Mataracı Kara, Ayse T. Jannuzzi and Berna Ozbek Celik

Drug Development Research, 2019, 80, 1098
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Novel azanaphtoquinone compounds with aromatic amino moiety: Synthesis, structural characterization, and antimicrobial features

Nilüfer Bayrak

Journal of Molecular Structure, 2019, 1195, 411
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Synthesis, Electrochemistry, DFT Calculations, Antimicrobial Properties and X‐ray Crystal Structures of Some NH‐ and/or S‐ Substituted‐1,4‐quinones

Aysecik Kacmaz, Elif Turker Acar, Gulten Atun, Kerem Kaya, Belgi Diren Sigirci and Funda Bagcigil

ChemistrySelect, 2018, 3, 8615
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Highly Active Small Aminated Quinolinequinones against Drug-Resistant Staphylococcus aureus and Candida albicans

Hatice Yıldırım, Nilüfer Bayrak, Mahmut Yıldız, Fatıma Nur Yılmaz, Emel Mataracı-Kara, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Molecules, 2022, 27, 2923
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Design, synthesis, characterization, and antimicrobial activity of novel piperazine substituted 1,4-benzoquinones

Mahmut Yıldız

Journal of Molecular Structure, 2020, 1203, 127422
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Advances in structural modification of natural products with antimicrobial activity

Jia-Hong Ju, Xiao-Ting Li, Qing-Kun Shen, Hong-Yan Guo, Zhe-Shan Quan and Xiu-Mei Yin

Fitoterapia, 2025, 186, 106815
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In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment

Halilibrahim Ciftci, Belgin Sever, Firdevs Ocak, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hasan DeMirci, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Molecules, 2022, 27, 693
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Exploring the Antibacterial and Antiparasitic Activity of Phenylaminonaphthoquinones—Green Synthesis, Biological Evaluation and Computational Study

Sussan Lopez-Mercado, Cinthya Enríquez, Jaime A. Valderrama, Ricardo Pino-Rios, Liliana Ruiz-Vásquez, Lastenia Ruiz Mesia, Gabriel Vargas-Arana, Pedro Buc Calderon and Julio Benites

IJMS, 2024, 25, 10670
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Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs

Nilüfer Bayrak, Halil I. Ciftci, Mahmut Yıldız, Hatice Yıldırım, Belgin Sever, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and Amaç Fatih Tuyun

Chemico-Biological Interactions, 2021, 345, 109555
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How to Achieve Better Results Using PASS-Based Virtual Screening: Case Study for Kinase Inhibitors

Pavel V. Pogodin, Alexey A. Lagunin, Anastasia V. Rudik, Dmitry A. Filimonov, Dmitry S. Druzhilovskiy, Mark C. Nicklaus and Vladimir V. Poroikov

Front. Chem., 2018, 6
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A new family of azanaphthoquinones for antimicrobial evaluation

Nilüfer Bayrak

Chemistry Central Journal, 2018, 12
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