Issue 1, 2023

Biomineralization-inspired sandwich dentin desensitization strategy based on multifunctional nanocomposite with yolk–shell structure

Abstract

Dentin hypersensitivity (DH) treatment is far from being unequivocal in providing a superior strategy that combines immediate and long-term efficiency of dentinal tubule (DT) occlusion and clinical applicability. In order to achieve this aim, a type of multifunctional yolk–shell nanocomposite with acid resistance, mechanical resistance and biomineralization properties was developed in this study, which consists of a silica/mesoporous titanium–zirconium nanocarrier (STZ) and poly(allylamine hydrochloride) (PAH)-stabilized amorphous calcium phosphate (ACP) liquid precursor. First, the nanocomposite, named as PSTZ, immediately occluded DTs and demonstrated outstanding acid and mechanical resistance. Second, the PSTZ nanocomposite induced intrafibrillar mineralization of single-layer collagen fibrils and remineralization of demineralized dentin matrix. Finally, PSTZ promoted the odontogenic differentiation of dental pulp stem cells by releasing ACP and silicon ions. The reconstruction of the dentin-mimicking hierarchical structure and the introduction of newly formed minerals in the upper, middle and lower segments of DTs, defined as sandwich-like structures, markedly reduced the permeability and achieved superior long-term sealing effects. The nanocomposite material based on mesoporous yolk–shell carriers and liquid-phase mineralized precursors developed in this study represents a versatile biomimetic sandwich desensitization strategy and offers fresh insight into the clinical management of DH.

Graphical abstract: Biomineralization-inspired sandwich dentin desensitization strategy based on multifunctional nanocomposite with yolk–shell structure

Supplementary files

Article information

Article type
Paper
Submitted
11 Way 2022
Accepted
07 Xim 2022
First published
08 Xim 2022

Nanoscale, 2023,15, 127-143

Biomineralization-inspired sandwich dentin desensitization strategy based on multifunctional nanocomposite with yolk–shell structure

L. Yi, H. Wu, Y. Xu, J. Yu, Y. Zhao, H. Yang and C. Huang, Nanoscale, 2023, 15, 127 DOI: 10.1039/D2NR04993G

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