Issue 5, 2022

A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

Abstract

A hydrogel scaffold with a non-fouling but specific cancer cell-adhesive surface was fabricated through surface modification using β-cyclodextrin-based host–guest chemistry. Interestingly, the hydrogel surface not only selectively captured specific cancer cells, but also grew the cells into multicellular spheroids. The spheroids could be released without damaging the cell viability through replacing the host moieties on the scaffold, and the released spheroids showed no changes in size or morphology.

Graphical abstract: A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

Supplementary files

Article information

Article type
Communication
Submitted
17 Dit 2021
Accepted
08 Kax 2021
First published
08 Kax 2021

Chem. Commun., 2022,58, 681-684

A hydrogel with supramolecular surface functionalization for cancer cell capture and multicellular spheroid growth and release

Y. Wen, N. N. Mensah, X. Song, J. Zhu, W. S. Tan, X. Chen and J. Li, Chem. Commun., 2022, 58, 681 DOI: 10.1039/D1CC05846K

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