Issue 42, 2019

D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

Abstract

NIR-II fluorescence imaging has great potential in diagnosis, but the quantum efficiency of contrast agents is an urgent problem to be solved. We synthesized two new multifunctional polymers, P-TT and P-DPP, with a tetrahedral C (sp3) and branched alkyl chains in the main chain, which were beneficial to obtain high quantum efficiency. P-TT and P-DPP showed absorption peaks of 686 nm and 763 nm, respectively, and fluorescence emission peaks of 1071 nm and 1066 nm, respectively. The photothermal effect of P-DPP can reach 52 °C, and the quantum yield reaches 1.5%, which was three times higher than that of nanotube fluorophores (quantum yield 0.4%). P-DPP is used for stable fluorescence imaging of blood vessels and photoacoustic imaging of nude mice, and successfully applied to phototherapy of nude mouse tumours.

Graphical abstract: D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

Supplementary files

Article information

Article type
Paper
Submitted
15 Qas 2019
Accepted
16 Way 2019
First published
20 Way 2019

J. Mater. Chem. B, 2019,7, 6576-6584

D–A polymers for fluorescence/photoacoustic imaging and characterization of their photothermal properties

Y. Zhu, C. Gu, Y. Miao, B. Yu, Y. Shen and H. Cong, J. Mater. Chem. B, 2019, 7, 6576 DOI: 10.1039/C9TB01196J

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