Issue 19, 2019

Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy

Abstract

Nanotheranostic reagents that integrate magnetic resonance imaging (MRI) and photothermal therapy (PTT) offer a promising strategy for the treatment of human disease. However, classic gadolinium (Gd)-based T1-MRI contrast agents are limited by their low relaxivity. To address this, we produced Gd-loaded Tobacco mosaic virus (TMV) particles coated with the mussel-inspired biopolymer polydopamine (PDA). Such biocompatible nanotheranostic reagents can be used to facilitate PTT, guided by multimodal magnetic resonance/photoacoustic imaging. The r1-relaxivity of the Gd-TMV–PDA particles at 60 MHz was ∼80 mM−1 s−1, compared to 13.63 mM−1 s−1 for the uncoated Gd-TMV particles. The Gd-TMV–PDA particles also promoted strong near-infrared absorption with high photothermal conversion efficiency (28.9%) and demonstrated excellent photoacoustic contrast. Multimodal imaging and PTT resulted in the effective killing of PC-3 prostate cancer cells. Gd-TMV–PDA nanoparticles therefore offer a promising theranostic approach that can now be tested in vivo in cancer models.

Graphical abstract: Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy

Supplementary files

Article information

Article type
Paper
Submitted
09 Cig 2019
Accepted
20 Agd 2019
First published
08 Cax 2019

Nanoscale, 2019,11, 9760-9768

Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy

H. Hu, Q. Yang, S. Baroni, H. Yang, S. Aime and N. F. Steinmetz, Nanoscale, 2019, 11, 9760 DOI: 10.1039/C9NR02065A

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