Issue 20, 2018

Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

Abstract

A carbene-catalyzed enantioselective cycloaddition reaction between enals and cyclic ketiminophosphonates is disclosed. α-Amino phosphonates bearing sophisticated fused heterocycles and quaternary carbons are afforded with excellent enantioselectivities. The α-amino phosphonate products from our approach exhibit encouraging anti-bacterial activities against X. oryzae pv. oryzae, the bacteria that cause serious diseases to rice and other plants.

Graphical abstract: Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

Supplementary files

Article information

Article type
Research Article
Submitted
14 Leq 2018
Accepted
12 Way 2018
First published
13 Way 2018

Org. Chem. Front., 2018,5, 2992-2996

Enantioselective access to multi-cyclic α-amino phosphonates via carbene-catalyzed cycloaddition reactions between enals and six-membered cyclic imines

J. Sun, C. Mou, C. Liu, R. Huang, S. Zhang, P. Zheng and Y. R. Chi, Org. Chem. Front., 2018, 5, 2992 DOI: 10.1039/C8QO00877A

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