Issue 50, 2018

Expanding the limit of Pd-catalyzed decarboxylative benzylations

Abstract

The Pd-catalyzed decarboxylative cross-coupling of electron-deficient aryl acetates with aryl bromides is reported. The method widens the scope of benzylic partners that can undergo efficient reactivity from highly activated nitrophenylacetates established previously, to a diverse series of substrates bearing modestly stabilizing groups, allowing direct access to functionalized diarylmethanes. Mechanistic studies support the role of dienolates as key intermediates in the coupling process.

Graphical abstract: Expanding the limit of Pd-catalyzed decarboxylative benzylations

Supplementary files

Article information

Article type
Communication
Submitted
26 Cig 2018
Accepted
17 Agd 2018
First published
17 Agd 2018

Chem. Commun., 2018,54, 6835-6838

Expanding the limit of Pd-catalyzed decarboxylative benzylations

D. Kong, P. J. Moon, W. Qian and R. J. Lundgren, Chem. Commun., 2018, 54, 6835 DOI: 10.1039/C8CC02380H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements