Issue 10, 2017

Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

Abstract

Despite its synthetic potential, intramolecular acylation by the Minisci reaction remains unexplored. The development of a new intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones is described. Distinct from the current literature known approaches for Minisci acylation, the report described herein features a method that: (a) avoids the use of silver that is invariably used in Minisci acylation, (b) does not require any acidic conditions for the activation of pyridines, and (c) shows tolerance to functional groups under neutral conditions.

Graphical abstract: Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

Supplementary files

Article information

Article type
Paper
Submitted
12 Qun 2017
Accepted
10 Nah 2017
First published
10 Nah 2017

Org. Biomol. Chem., 2017,15, 2199-2210

Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

J. K. Laha, K. V. Patel, G. Dubey and K. P. Jethava, Org. Biomol. Chem., 2017, 15, 2199 DOI: 10.1039/C7OB00077D

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