Issue 17, 2016

Targeting mitochondrial DNA with a two-photon active Ru(ii) phenanthroline derivative

Abstract

As a semi-autonomous organelle, the eukaryotic mitochondrion possesses an individual DNA and protein synthesizing system. Therefore, the mitochondrial DNA-targeting probes are powerful tools to understand the functions in physiological processes. Herein, we report a novel Ru(II) complex (HLRu) based on a phenanthroline derivative to target mitochondrial DNA. The nonlinear optical property study revealed a reverse nonlinear optical refraction character from self-focusing to self-defocusing response before and after complexation with Ru(II). Furthermore, the two-photon absorption and high biocompatibility of complex HLRu highlight its potential applications in biological processes. It was found that complex HLRu specifically binds to mitochondrial DNA in living cells and enables imaging of tissues with minimal auto-fluorescence. As a result, this complex HLRu probe offers a promising platform to directly monitor mitochondrial DNA in living cells.

Graphical abstract: Targeting mitochondrial DNA with a two-photon active Ru(ii) phenanthroline derivative

Supplementary files

Article information

Article type
Paper
Submitted
20 Nah 2016
Accepted
01 Agd 2016
First published
01 Agd 2016

J. Mater. Chem. B, 2016,4, 2895-2902

Targeting mitochondrial DNA with a two-photon active Ru(II) phenanthroline derivative

H. Wang, X. Tian, L. Guan, Q. Zhang, S. Zhang, H. Zhou, J. Wu and Y. Tian, J. Mater. Chem. B, 2016, 4, 2895 DOI: 10.1039/C6TB00433D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements