Issue 3, 2015

Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles

Abstract

Efficient and atom-economical access to indolizines has been developed by a Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with various nucleophiles through simultaneous formation of a C–N bond and a remote carbon–nucleophile bond. 1,3-Dicarbonyl compounds, indoles, amides, alcohol, and even water, were used as nucleophiles in this reaction. Good to excellent yields of the corresponding indolizines were obtained under mild reaction conditions.

Graphical abstract: Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles

Supplementary files

Article information

Article type
Research Article
Submitted
18 Kax 2014
Accepted
13 Qun 2015
First published
14 Qun 2015

Org. Chem. Front., 2015,2, 226-230

Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles

R. Liu, Z. Cai, C. Lu, S. Ye, B. Xiang, J. Gao and Y. Jia, Org. Chem. Front., 2015, 2, 226 DOI: 10.1039/C4QO00336E

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