Issue 17, 2015

DNA–bare gold affinity interactions: mechanism and applications in biosensing

Abstract

The adsorption of DNA onto gold due to affinity interactions is highly desirable for developing low-cost, convenient and sensitive biosensors. To date, DNA–gold adsorption phenomenon has been demonstrated as one of the most promising physical mechanisms for achieving precise control over unmodified gold nanoparticles (AuNPs) aggregation, and DNA monolayer formation on gold surfaces. The adsorption phenomenon is exquisitely controlled by many factors including intermolecular forces, along with DNA composition and sequence. The understanding and manipulation of these factors have allowed broad biosensing applications and notably, sequence-dependent DNA–gold adsorption which may be highly relevant for DNA methylation detection in cancer. Herein, we review the underlying principles governing DNA–gold adsorption as well as recent biosensing strategies based on differential ssDNA/dsDNA–AuNPs adsorption and sequence-dependent DNA–gold adsorption. Finally, we have also contributed insights regarding the future trend of DNA–gold adsorption-based biosensors.

Graphical abstract: DNA–bare gold affinity interactions: mechanism and applications in biosensing

Article information

Article type
Critical Review
Submitted
09 Qas 2015
Accepted
04 Qad 2015
First published
06 Qad 2015

Anal. Methods, 2015,7, 7042-7054

DNA–bare gold affinity interactions: mechanism and applications in biosensing

K. M. Koo, A. A. I. Sina, L. G. Carrascosa, M. J. A. Shiddiky and M. Trau, Anal. Methods, 2015, 7, 7042 DOI: 10.1039/C5AY01479D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements