Issue 4, 2015

A paperfluidic device for dental applications using a novel patterning technique

Abstract

Dental caries is an irreversible and potentially debilitating disease that can ultimately lead to the loss of the affected tooth structure. Due to a lack of awareness, caries is detected much later after its onset. Moreover, people do not have access to dental care or information in the rural areas of several developing countries. Hence, there is a need for a cheap and disposable point-of-care screening test to determine one's oral health. To cater to this unmet need, we have developed a paperfluidic chip that measures salivary pH to estimate its buffering capacity and also tests susceptibility to caries by checking for salivary reductase. The results of our paper-based reductase assay of 72 samples correlated well with the results obtained using the standard tube-based assay performed in dental clinics. Further, the results of the paper-based pH test matched with those of the caries test, i.e. those with lower saliva pH showed higher susceptibility to caries (since acidic environments promote caries). Here, we also report a new and green technique to chemically pattern paper by printing olive oil through an inkjet printer and turning paper (cellulose) hydrophobic in the oil-treated regions through heat-assisted esterification. In addition to patterning hydrophobic regions on paper, the same inkjet printer was used to print all the assay reagents, thus making our paperfluidic chip completely printable. Since our device is cheap, disposable and can be easily manufactured in large volumes by printing, it is suitable for regular monitoring of oral health as well as providing a basic screening test to those without routine access to dentists.

Graphical abstract: A paperfluidic device for dental applications using a novel patterning technique

Supplementary files

Article information

Article type
Paper
Submitted
24 Xim 2014
Accepted
12 Kax 2014
First published
15 Kax 2014

Anal. Methods, 2015,7, 1293-1299

A paperfluidic device for dental applications using a novel patterning technique

A. Jagirdar, P. Shetty, S. Satti, S. Garg and D. Paul, Anal. Methods, 2015, 7, 1293 DOI: 10.1039/C4AY02802C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements